BAIT
M
ORF5, 5, matrix protein, mem, M protein, SARS-CoV M, SARS-CoV Mem, matrix, membrane, VME1_CVHSA, PRO_0000106035, SARS-CoV-5
Membrane protein; M protein; E1 glycoprotein; Matrix glycoprotein; Membrane glycoprotein
GO Process (0)
GO Function (0)
GO Component (0)
Severe acute respiratory syndrome coronavirus
PREY
STT3B
CDG1X, SIMP, STT3-B
STT3B, subunit of the oligosaccharyltransferase complex (catalytic)
GO Process (6)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
The COVID-19 (Coronavirus disease-2019) pandemic, caused by the SARS-CoV-2 coronavirus, is a significant threat to public health and the global economy. SARS-CoV-2 is closely related to the more lethal but less transmissible coronaviruses SARS-CoV-1 and MERS-CoV. Here, we have carried out comparative viral-human protein-protein interaction and viral protein localization analysis for all three viruses. Subsequent functional genetic screening identified host ... [more]
Science Oct. 15, 2020; (); [Pubmed: 33060197]
Quantitative Score
- 0.99097 [MiST Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions were identified using a two step filtering process with the final criteria including a MiST score >= 0.6, SAINTexpress BFDR =< 0.05 and average spectral counts >= 2. The MiST score is provided in the score column.
Curated By
- BioGRID