BAIT
NSP13AB
nsp13, sars1ab, orf1ab, SARS-CoV nsp13ab, SARS-CoV nsp13, SARS-CoV sars1ab, orf1ab-nsp13, orf1ab-nsp13ab, pp1ab, Helicase, Hel, R1AB_CVHSA, PRO_0000037319, SARS-CoV-1ab-nsp13ab
Helicase; Hel; Non-structural protein 13
GO Process (0)
GO Function (0)
GO Component (0)
Severe acute respiratory syndrome coronavirus
PREY
LMO7
FBX20, FBXO20, LOMP, RP11-332E3.2
LIM domain 7
GO Process (1)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
The COVID-19 (Coronavirus disease-2019) pandemic, caused by the SARS-CoV-2 coronavirus, is a significant threat to public health and the global economy. SARS-CoV-2 is closely related to the more lethal but less transmissible coronaviruses SARS-CoV-1 and MERS-CoV. Here, we have carried out comparative viral-human protein-protein interaction and viral protein localization analysis for all three viruses. Subsequent functional genetic screening identified host ... [more]
Science Oct. 15, 2020; (); [Pubmed: 33060197]
Quantitative Score
- 0.61893 [MiST Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions were identified using a two step filtering process with the final criteria including a MiST score >= 0.6, SAINTexpress BFDR =< 0.05 and average spectral counts >= 2. The MiST score is provided in the score column.
Curated By
- BioGRID