PRMT4A
Gene Ontology Biological Process
Gene Ontology Molecular Function- [myelin basic protein]-arginine N-methyltransferase activity [IDA]
- histone-arginine N-methyltransferase activity [IDA]
- methyltransferase activity [ISS]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IPI]
- protein-arginine omega-N asymmetric methyltransferase activity [IDA]
- protein-arginine omega-N monomethyltransferase activity [IDA]
- [myelin basic protein]-arginine N-methyltransferase activity [IDA]
- histone-arginine N-methyltransferase activity [IDA]
- methyltransferase activity [ISS]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IPI]
- protein-arginine omega-N asymmetric methyltransferase activity [IDA]
- protein-arginine omega-N monomethyltransferase activity [IDA]
PRMT4B
Gene Ontology Biological Process
Gene Ontology Molecular Function- [myelin basic protein]-arginine N-methyltransferase activity [IDA]
- histone-arginine N-methyltransferase activity [IDA]
- methyltransferase activity [ISS]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IPI]
- protein-arginine omega-N asymmetric methyltransferase activity [IDA]
- protein-arginine omega-N monomethyltransferase activity [IDA]
- [myelin basic protein]-arginine N-methyltransferase activity [IDA]
- histone-arginine N-methyltransferase activity [IDA]
- methyltransferase activity [ISS]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IPI]
- protein-arginine omega-N asymmetric methyltransferase activity [IDA]
- protein-arginine omega-N monomethyltransferase activity [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Redundant requirement for a pair of PROTEIN ARGININE METHYLTRANSFERASE4 homologs for the proper regulation of Arabidopsis flowering time.
CARM1/PRMT4 (for COACTIVATOR-ASSOCIATED ARGININE METHYLTRANSFERASE1/PROTEIN ARGININE METHYLTRANSFERASE4) catalyzes asymmetric dimethylation on arginine (Arg), and its functions in gene regulation is understood only in animal systems. Here, we describe AtPRMT4a and AtPRMT4b as a pair of Arabidopsis (Arabidopsis thaliana) homologs of mammalian CARM1/PRMT4. Recombinant AtPRMT4a and AtPRMT4b could asymmetrically dimethylate histone H3 at Arg-2, Arg-17, Arg-26, and myelin basic protein in ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PRMT4B PRMT4A | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | - | BioGRID | - |
Curated By
- BioGRID