BAIT
FRS2
4732458E18, C330018A15Rik, Frs2alpha, SNT1
fibroblast growth factor receptor substrate 2
GO Process (17)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- activation of MAPK activity [IMP]
- anterior/posterior axis specification, embryo [IMP]
- fibroblast growth factor receptor signaling pathway [IGI, IMP, ISO]
- forebrain development [IMP]
- gastrulation with mouth forming second [IMP]
- lens development in camera-type eye [IMP]
- lens fiber cell development [IGI, IMP]
- neuroblast proliferation [IGI, IMP]
- optic placode formation involved in camera-type eye formation [IMP]
- organ induction [IMP]
- positive regulation of signal transduction [IDA]
- prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [IMP]
- regulation of ERK1 and ERK2 cascade [IMP]
- regulation of apoptotic process [IMP]
- regulation of epithelial cell proliferation [IMP]
- transmembrane receptor protein tyrosine kinase signaling pathway [IDA]
- ventricular septum development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PRKCI
DXS1179E, PKCI, nPKC-iota
protein kinase C, iota
GO Process (21)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- cell junction assembly [TAS]
- cell-cell junction organization [IMP, TAS]
- cellular response to insulin stimulus [ISS]
- cytoskeleton organization [NAS]
- establishment or maintenance of epithelial cell apical/basal polarity [TAS]
- membrane organization [NAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of glial cell apoptotic process [IMP]
- negative regulation of neuron apoptotic process [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of endothelial cell apoptotic process [IMP]
- positive regulation of establishment of protein localization to plasma membrane [ISS]
- positive regulation of glial cell proliferation [IMP]
- positive regulation of glucose import [ISS]
- positive regulation of neuron projection development [IMP]
- protein phosphorylation [IDA]
- protein targeting to membrane [NAS]
- secretion [NAS]
- tight junction assembly [TAS]
- vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling.
FRS2 is a docker protein that recruits signaling proteins to the plasma membrane in fibroblast growth factor signal transduction. We report here that FRS2 was associated with PKC lambda when Swiss 3T3 cells were stimulated with basic fibroblast growth factor. PKC zeta, the other member of the atypical PKC subfamily, could also bind FRS2. The association between FRS2 and PKC ... [more]
J. Biol. Chem. Jul. 02, 1999; 274(27);19025-34 [Pubmed: 10383403]
Throughput
- Low Throughput
Curated By
- BioGRID