ING2
Gene Ontology Biological Process
- chromatin modification [ISS]
- male germ-line stem cell asymmetric division [ISS]
- male meiosis I [ISS]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [TAS]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of transforming growth factor beta receptor signaling pathway [IDA]
- regulation of cellular senescence [NAS]
- regulation of response to DNA damage stimulus [NAS]
- regulation of transcription, DNA-templated [IDA]
- seminiferous tubule development [ISS]
- signal transduction [TAS]
- sperm motility [ISS]
- spermatid development [ISS]
- spermatogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SMARCC2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.
Members of the ING family of tumor suppressors regulate cell cycle progression, apoptosis, and DNA repair as important cofactors of p53. ING1 and ING3 are stable components of the mSin3A HDAC and Tip60/NuA4 HAT complexes, respectively. We now report the purification of the three remaining human ING proteins. While ING2 is in an HDAC complex similar to ING1, ING4 associates ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID