BAIT
SLX4
BTBD12, FANCP, MUS312
SLX4 structure-specific endonuclease subunit
GO Process (7)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IDA]
- DNA double-strand break processing involved in repair via single-strand annealing [IMP]
- DNA repair [IMP]
- double-strand break repair via homologous recombination [IMP]
- nucleotide-excision repair [IMP]
- positive regulation of catalytic activity [IDA]
- response to intra-S DNA damage checkpoint signaling [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PSMB4
HN3, HsN3, PROS-26, PROS26
proteasome (prosome, macropain) subunit, beta type, 4
GO Process (21)
GO Function (0)
GO Component (6)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [TAS]
- G1/S transition of mitotic cell cycle [TAS]
- RNA metabolic process [TAS]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- apoptotic process [TAS]
- cellular nitrogen compound metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- mitotic cell cycle [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- protein polyubiquitination [TAS]
- regulation of apoptotic process [TAS]
- regulation of cellular amino acid metabolic process [TAS]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- small molecule metabolic process [TAS]
- viral process [TAS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.
Structure-specific endonucleases mediate cleavage of DNA structures formed during repair of collapsed replication forks and double-strand breaks (DSBs). Here, we identify BTBD12 as the human ortholog of the budding yeast DNA repair factor Slx4p and D. melanogaster MUS312. Human SLX4 forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases and also associates with MSH2/MSH3 mismatch repair complex, telomere ... [more]
Cell Jul. 10, 2009; 138(1);63-77 [Pubmed: 19596235]
Quantitative Score
- 1.74 [Confidence Score]
Throughput
- High Throughput
Curated By
- BioGRID