BAIT
SRRM1
160-KD, POP101, SRM160
serine/arginine repetitive matrix 1
GO Process (8)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
KMT2D
AAD10, ALR, CAGL114, KABUK1, KMS, MLL2, MLL4, TNRC21
lysine (K)-specific methyltransferase 2D
GO Process (9)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- chromatin silencing [ISS]
- histone H3-K4 methylation [ISS]
- oocyte growth [ISS]
- oogenesis [ISS]
- positive regulation of cell proliferation [IMP]
- positive regulation of intracellular estrogen receptor signaling pathway [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription, DNA-templated [NAS]
- response to estrogen [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.
In this study, we describe a rapid immunoaffinity purification procedure for gel-free tandem mass spectrometry-based analysis of endogenous protein complexes and apply it to the characterization of complexes containing the SRm160 (serine/arginine repeat-related nuclear matrix protein of 160 kDa) splicing coactivator. In addition to promoting splicing, SRm160 stimulates 3'-end processing via its N-terminal PWI nucleic acid-binding domain and is found ... [more]
J. Biol. Chem. Dec. 23, 2005; 280(51);42227-36 [Pubmed: 16159877]
Throughput
- Low Throughput
Curated By
- BioGRID