BAIT

PUB12

AtPUB12, F8N16.12, F8N16_12, PLANT U-BOX 12, AT2G28830
U-box E3 ubiquitin ligase
GO Process (2)
GO Function (1)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Arabidopsis thaliana (Columbia)
PREY

FLS2

FLAGELLIN-SENSITIVE 2, MPL12.13, MPL12.8, MPL12_13, AT5G46330
LRR receptor-like serine/threonine-protein kinase FLS2
Arabidopsis thaliana (Columbia)

Biochemical Activity (Ubiquitination)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Direct ubiquitination of pattern recognition receptor FLS2 attenuates plant innate immunity.

Lu D, Lin W, Gao X, Wu S, Cheng C, Avila J, Heese A, Devarenne TP, He P, Shan L

Innate immune responses are triggered by the activation of pattern-recognition receptors (PRRs). The Arabidopsis PRR FLAGELLIN-SENSING 2 (FLS2) senses bacterial flagellin and initiates immune signaling through association with BAK1. The molecular mechanisms underlying the attenuation of FLS2 activation are largely unknown. We report that flagellin induces recruitment of two closely related U-box E3 ubiquitin ligases, PUB12 and PUB13, to FLS2 ... [more]

Science Jun. 17, 2011; 332(6036);1439-42 [Pubmed: 21680842]

Throughput

  • Low Throughput

Curated By

  • BioGRID