BAIT
BST2
CD317, TETHERIN
bone marrow stromal cell antigen 2
GO Process (19)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- cell proliferation [TAS]
- cell-cell signaling [TAS]
- defense response to virus [IDA]
- humoral immune response [TAS]
- innate immune response [IDA]
- multicellular organismal development [TAS]
- negative regulation of cell growth [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of endopeptidase activity [IDA]
- negative regulation of intracellular transport of viral material [IDA]
- negative regulation of plasmacytoid dendritic cell cytokine production [IDA]
- negative regulation of viral genome replication [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- regulation of actin cytoskeleton organization [ISS]
- response to interferon-alpha [ISS]
- response to interferon-beta [ISS]
- response to interferon-gamma [ISS]
- response to virus [IDA]
- signal transduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TFRC
CD71, T9, TFR, TFR1, TR, TRFR, p90
transferrin receptor
GO Process (6)
GO Function (5)
GO Component (14)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- blood microparticle [IDA]
- cell surface [IDA]
- coated pit [IDA]
- cytoplasmic membrane-bounded vesicle [IDA]
- endosome [IDA]
- extracellular region [IDA]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- integral component of plasma membrane [TAS]
- intracellular membrane-bounded organelle [IDA]
- membrane [NAS]
- plasma membrane [TAS]
- recycling endosome [IDA]
- vesicle [IDA]
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Serine-threonine ubiquitination mediates downregulation of BST-2/tetherin and relief of restricted virion release by HIV-1 Vpu.
The HIV-1 protein Vpu counteracts the antiviral activity of the innate restriction factor BST-2/tetherin by a mechanism that partly depends on its interaction with β-TrCP, a substrate adaptor for an SCF (Skp-Cullin 1-F box) E3 ubiquitin ligase complex. This suggests that Vpu stimulates the ubiquitination of BST-2 and that this underlies the relief of restriction. Here, we show that Vpu ... [more]
J. Virol. Jan. 01, 2011; 85(1);51-63 [Pubmed: 20980512]
Throughput
- Low Throughput
Curated By
- BioGRID