ABCA1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP]
- apolipoprotein A-I-mediated signaling pathway [IDA]
- cellular lipid metabolic process [TAS]
- cholesterol efflux [IDA, IMP]
- cholesterol homeostasis [IDA]
- cholesterol metabolic process [IDA]
- endosomal transport [IDA]
- high-density lipoprotein particle assembly [IMP]
- interleukin-1 beta secretion [IMP]
- intracellular cholesterol transport [IMP]
- lipoprotein metabolic process [TAS]
- lysosome organization [IDA]
- negative regulation of cholesterol storage [TAS]
- negative regulation of macrophage derived foam cell differentiation [TAS]
- phospholipid efflux [IDA, IMP]
- phospholipid homeostasis [IMP]
- platelet dense granule organization [IMP]
- positive regulation of cAMP biosynthetic process [IMP]
- regulation of Cdc42 protein signal transduction [IMP]
- response to laminar fluid shear stress [IEP]
- response to low-density lipoprotein particle [IEP]
- reverse cholesterol transport [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- ATP binding [IDA]
- ATPase binding [IPI]
- anion transmembrane transporter activity [ISS]
- apolipoprotein A-I binding [IPI]
- apolipoprotein A-I receptor activity [IDA]
- apolipoprotein binding [IPI]
- cholesterol binding [IC]
- cholesterol transporter activity [IDA]
- phospholipid binding [IC]
- phospholipid transporter activity [IDA]
- protein binding [IPI]
- receptor binding [IPI]
- small GTPase binding [IPI]
- syntaxin binding [IPI]
- ATP binding [IDA]
- ATPase binding [IPI]
- anion transmembrane transporter activity [ISS]
- apolipoprotein A-I binding [IPI]
- apolipoprotein A-I receptor activity [IDA]
- apolipoprotein binding [IPI]
- cholesterol binding [IC]
- cholesterol transporter activity [IDA]
- phospholipid binding [IC]
- phospholipid transporter activity [IDA]
- protein binding [IPI]
- receptor binding [IPI]
- small GTPase binding [IPI]
- syntaxin binding [IPI]
Gene Ontology Cellular Component
STX12
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells.
The ATP-binding cassette transporter A1 (ABCA1) facilitates the cellular release of cholesterol and choline-phospholipids to apolipoprotein A-I (apoA-I) and several studies indicate that vesicular transport is associated with ABCA1 function. Syntaxins play a major role in vesicular fusion and have also been demonstrated to interact with members of the ABC-transporter family. Therefore, we focused on the identification of syntaxins that ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| STX12 ABCA1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID