BAIT
ITSN2
PRO2015, SH3D1B, SH3P18, SWA, SWAP
intersectin 2
GO Process (1)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ROCK1
P160ROCK, ROCK-I
Rho-associated, coiled-coil containing protein kinase 1
GO Process (20)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- Rho protein signal transduction [TAS]
- apoptotic process [TAS]
- axon guidance [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- leukocyte cell-cell adhesion [IDA]
- leukocyte migration [IDA]
- leukocyte tethering or rolling [IDA]
- membrane to membrane docking [IDA]
- myoblast migration [ISS]
- negative regulation of angiogenesis [IMP]
- positive regulation of focal adhesion assembly [ISS]
- regulation of actin cytoskeleton organization [TAS]
- regulation of cell adhesion [TAS]
- regulation of cell motility [TAS]
- regulation of establishment of cell polarity [TAS]
- regulation of focal adhesion assembly [TAS]
- regulation of keratinocyte differentiation [IMP]
- regulation of stress fiber assembly [TAS]
- signal transduction [TAS]
- smooth muscle contraction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Intersectin (ITSN) Family of Scaffolds Function as Molecular Hubs in Protein Interaction Networks.
Members of the intersectin (ITSN) family of scaffold proteins consist of multiple modular domains, each with distinct ligand preferences. Although ITSNs were initially implicated in the regulation of endocytosis, subsequent studies have revealed a more complex role for these scaffold proteins in regulation of additional biochemical pathways. In this study, we performed a high throughput yeast two-hybrid screen to identify ... [more]
PLoS ONE May. 05, 2012; 7(4);e36023 [Pubmed: 22558309]
Throughput
- High Throughput
Curated By
- BioGRID