BAIT
CAND1
TIP120, TIP120A
cullin-associated and neddylation-dissociated 1
GO Process (4)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CD36
BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3
CD36 molecule (thrombospondin receptor)
GO Process (27)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- blood coagulation [TAS]
- cGMP-mediated signaling [IDA]
- cellular lipid metabolic process [TAS]
- cholesterol transport [ISS]
- innate immune response [TAS]
- lipid metabolic process [NAS]
- lipid storage [IMP]
- lipoprotein transport [IMP, TAS]
- long-chain fatty acid import [IDA]
- low-density lipoprotein particle clearance [IMP]
- nitric oxide mediated signal transduction [IDA]
- plasma lipoprotein particle clearance [ISS]
- plasma membrane long-chain fatty acid transport [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of cell-matrix adhesion [IDA]
- positive regulation of macrophage derived foam cell differentiation [IMP]
- small molecule metabolic process [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics.
Dynamic reorganization of signaling systems frequently accompanies pathway perturbations, yet quantitative studies of network remodeling by pathway stimuli are lacking. Here, we report the development of a quantitative proteomics platform centered on multiplex absolute quantification (AQUA) technology to elucidate the architecture of the cullin-RING ubiquitin ligase (CRL) network and to evaluate current models of dynamic CRL remodeling. Current models suggest ... [more]
Cell Dec. 10, 2010; 143(6);951-65 [Pubmed: 21145461]
Throughput
- High Throughput
Ontology Terms
- cell line: hek-293t cell (BTO:0002181)
Additional Notes
- All data was filtered to a 1% false discovery rate (peptide level) prior to analysis using CompPASS to identify high confidence candidate interacting proteins
- TAP-tagged CAND1
- exogenous expression of bait
Curated By
- BioGRID