BAIT

SPRTN

C1orf124, DDDL1880, DVC1, PRO4323, Spartan, dJ876B10.3, RP5-876B10.3
SprT-like N-terminal domain
UPS Project
GO Process (4)
GO Function (3)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

CAND1

TIP120, TIP120A
cullin-associated and neddylation-dissociated 1
UPS Project
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

PCNA-binding protein C1orf124 is a regulator of translesion synthesis.

Ghosal G, Leung JW, Nair BC, Fong KW, Chen J

DNA damage-induced PCNA ubiquitination serves as the key event mediating post-replication repair (PRR). PRR involves either translesion synthesis (TLS) or damage avoidance via template switching. In this study, we have identified and characterized C1orf124 as a regulator of TLS. C1orf124 colocalizes and interacts with unmodified and ubiquitinated PCNA (Ub-PCNA) at UV induced damage sites, which require the PIP box and ... [more]

J. Biol. Chem. Aug. 17, 2012; 0(0); [Pubmed: 22902628]

Throughput

  • Low Throughput

Additional Notes

  • figure 2A.

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
SPRTN CAND1
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Low-BioGRID
-

Curated By

  • BioGRID