BAIT
FASLG
ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6
Fas ligand (TNF superfamily, member 6)
GO Process (16)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- T cell apoptotic process [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IGI, IMP, TAS]
- apoptotic process [TAS]
- apoptotic signaling pathway [IDA, TAS]
- cell-cell signaling [TAS]
- extrinsic apoptotic signaling pathway [IDA]
- extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- necroptotic process [IDA]
- necroptotic signaling pathway [IDA]
- negative regulation of angiogenesis [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- positive regulation of apoptotic process [IDA]
- positive regulation of endothelial cell apoptotic process [IDA]
- regulation of extrinsic apoptotic signaling pathway in absence of ligand [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BTK
AGMX1, AT, ATK, BPK, IMD1, PSCTK1, XLA, RP1-164F3.2
Bruton agammaglobulinemia tyrosine kinase
GO Process (25)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- B cell activation [TAS]
- B cell receptor signaling pathway [IBA, TAS]
- Fc-epsilon receptor signaling pathway [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- T cell receptor signaling pathway [IBA]
- adaptive immune response [IBA, TAS]
- apoptotic signaling pathway [TAS]
- calcium-mediated signaling [TAS]
- cell differentiation [IBA]
- innate immune response [IBA, TAS]
- intracellular signal transduction [TAS]
- mesoderm development [TAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- positive regulation of B cell differentiation [TAS]
- positive regulation of NF-kappaB transcription factor activity [TAS]
- protein phosphorylation [TAS]
- regulation of B cell apoptotic process [TAS]
- regulation of B cell cytokine production [TAS]
- regulation of cell proliferation [IBA]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.
Fas ligand is a cytotoxic effector molecule of T and NK cells which is characterized by an intracellular N-terminal polyproline region that serves as a docking site for SH3 and WW domain proteins. Several previously described Fas ligand-interacting SH3 domain proteins turned out to be crucial for the regulation of storage, expression and function of the death factor. Recent observations, ... [more]
BMC Immunol. Oct. 08, 2009; 10(0);53 [Pubmed: 19807924]
Throughput
- Low Throughput
Curated By
- BioGRID