BAIT
BTK
AGMX1, AT, ATK, BPK, IMD1, PSCTK1, XLA, RP1-164F3.2
Bruton agammaglobulinemia tyrosine kinase
GO Process (25)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- B cell activation [TAS]
- B cell receptor signaling pathway [IBA, TAS]
- Fc-epsilon receptor signaling pathway [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- T cell receptor signaling pathway [IBA]
- adaptive immune response [IBA, TAS]
- apoptotic signaling pathway [TAS]
- calcium-mediated signaling [TAS]
- cell differentiation [IBA]
- innate immune response [IBA, TAS]
- intracellular signal transduction [TAS]
- mesoderm development [TAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- positive regulation of B cell differentiation [TAS]
- positive regulation of NF-kappaB transcription factor activity [TAS]
- protein phosphorylation [TAS]
- regulation of B cell apoptotic process [TAS]
- regulation of B cell cytokine production [TAS]
- regulation of cell proliferation [IBA]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TLR9
CD289, UNQ5798/PRO19605
toll-like receptor 9
GO Process (33)
GO Function (2)
GO Component (13)
Gene Ontology Biological Process
- I-kappaB phosphorylation [IDA]
- defense response to Gram-negative bacterium [IMP]
- defense response to bacterium [NAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- maintenance of gastrointestinal epithelium [ISS]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of interleukin-6 production [ISS]
- negative regulation of interleukin-8 production [IDA]
- negative regulation of toll-like receptor signaling pathway [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of JNK cascade [IC]
- positive regulation of JUN kinase activity [IDA]
- positive regulation of NF-kappaB import into nucleus [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of chemokine production [IDA]
- positive regulation of inflammatory response [IC]
- positive regulation of interferon-alpha biosynthetic process [IDA]
- positive regulation of interferon-beta biosynthetic process [IDA]
- positive regulation of interferon-beta production [ISS]
- positive regulation of interferon-gamma biosynthetic process [IDA]
- positive regulation of interleukin-10 production [ISS]
- positive regulation of interleukin-12 production [ISS]
- positive regulation of interleukin-18 production [ISS]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of nitric-oxide synthase biosynthetic process [ISS]
- positive regulation of toll-like receptor signaling pathway [IDA]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of tumor necrosis factor production [ISS]
- response to molecule of bacterial origin [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [TAS]
- apical plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- cytoplasm [IDA]
- early phagosome [ISS]
- endolysosome membrane [TAS]
- endoplasmic reticulum [ISS]
- endoplasmic reticulum membrane [TAS]
- endosome [ISS]
- endosome membrane [TAS]
- extracellular region [NAS]
- lysosome [ISS]
- plasma membrane [IDA]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.
In this study we have identified members of the Toll-like receptor (TLR) family (namely, TLRs 4, 6, 8, and 9) as proteins to which the intracellular protein tyrosine kinase, Bruton's tyrosine kinase (Btk), binds. Detailed analysis of the interaction between Btk and TLR8 demonstrates that the presence of both Box 2 and 3 motifs in the Toll/interleukin-1 receptor domain was ... [more]
J. Biol. Chem. Jul. 11, 2003; 278(28);26258-64 [Pubmed: 12724322]
Throughput
- Low Throughput
Curated By
- BioGRID