BAIT

HK5

AHK5, CKI2, CYTOKININ INDEPENDENT 2, MAJ23.80, MAJ23_80, histidine kinase 5, AT5G10720
histidine kinase 5
Arabidopsis thaliana (Columbia)
PREY

AHP5

F21B7.5, histidine-containing phosphotransfer factor 5, AT1G03430
histidine-containing phosphotransfer protein 5
GO Process (3)
GO Function (2)
GO Component (2)
Arabidopsis thaliana (Columbia)

PCA

A Protein-Fragment Complementation Assay (PCA) is a protein-protein interaction assay in which a bait protein is expressed as fusion to one of the either N- or C- terminal peptide fragments of a reporter protein and prey protein is expressed as fusion to the complementary N- or C- terminal fragment of the same reporter protein. Interaction of bait and prey proteins bring together complementary fragments, which can then fold into an active reporter, e.g. the split-ubiquitin assay.

Publication

Structure-function analysis of Arabidopsis thaliana histidine kinase AHK5 bound to its cognate phosphotransfer protein AHP1.

Bauer J, Reiss K, Veerabagu M, Heunemann M, Harter K, Stehle T

The multi-step phosphorelay (MSP) system defines a key signal transduction pathway in plants and many eukaryotes. In this system, external stimuli first lead to the activation of a histidine kinase, followed by transfer of a phosphoryl group from the receiver domain of the kinase (HK(RD)) to downstream, cytosolic phosphotransfer proteins (HPs). In order to establish the determinants of specificity for ... [more]

Mol Plant Nov. 06, 2012; 0(0); [Pubmed: 23132142]

Throughput

  • Low Throughput

Curated By

  • BioGRID