An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Proteomic investigation of the interactome of FMNL1 in hematopoietic cells unveils a role in calcium-dependent membrane plasticity.

Han Y, Yu G, Sarioglu H, Caballero-Martinez A, Schlott F, Ueffing M, Haase H, Peschel C, Krackhardt AM

Formin-like 1 (FMNL1) is a formin-related protein highly expressed in hematopoietic cells and overexpressed in leukemias as well as diverse transformed cell lines. It has been described to play a role in diverse functions of hematopoietic cells such as phagocytosis of macrophages as well as polarization and cytotoxicity of T cells. However, the specific role of FMNL1 in these processes ... [more]

J Proteomics Jan. 14, 2013; 78(0);72-82 [Pubmed: 23182705]

Throughput

High Throughput

Curated By

BioGRID

Interaction Summary

FMNL1

Gene Ontology Biological Process

Gene Ontology Molecular Function

GTPase activating protein binding [IDA]Rac GTPase binding [ISS]actin filament binding [ISS]protein binding [IPI]

Gene Ontology Cellular Component

LMO7