BAIT
EPAS1
ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73
endothelial PAS domain protein 1
GO Process (6)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- cellular response to hypoxia [IDA, TAS]
- myoblast fate commitment [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- response to hypoxia [IDA]
- transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SMARCC2
BAF170, CRACC2, Rsc8
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
GO Process (6)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of HIF2 alpha nuclear interactome in melanoma cells reveals master proteins involved in melanoma development.
Hypoxia-inducible factors (HIF) are heterodimeric transcription factors that play a key role in cellular adaptation to hypoxia. HIF proteins are composed of an α subunit regulated by oxygen pressure (essentially HIF1α or HIF2α) and a constitutively expressed β subunit. These proteins are often overexpressed in cancer cells and HIF overexpression frequently correlates with poor prognosis, making HIF proteins promising therapeutic ... [more]
Mol. Cell Proteomics Dec. 28, 2012; 0(0); [Pubmed: 23275444]
Throughput
- High Throughput
Curated By
- BioGRID