COL5A1
Gene Ontology Biological Process
- blood vessel development [IMP]
- cell adhesion [ISO]
- cell migration [ISO]
- collagen biosynthetic process [ISO]
- collagen fibril organization [IGI, IMP, ISO]
- extracellular fibril organization [ISO]
- eye morphogenesis [ISO]
- heart morphogenesis [IGI]
- integrin biosynthetic process [ISO]
- negative regulation of endodermal cell differentiation [ISO]
- regulation of cellular component organization [IMP]
- skin development [IMP, ISO]
- tendon development [IGI, IMP]
- wound healing, spreading of epidermal cells [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SMAD1
Gene Ontology Biological Process
- BMP signaling pathway [IGI, IMP, ISO, TAS]
- MAPK cascade [IMP, ISO]
- SMAD protein complex assembly [ISO]
- bone development [IGI]
- cardiac muscle cell proliferation [IGI, IMP]
- cartilage development [IGI]
- cellular response to BMP stimulus [IGI]
- cellular response to organic cyclic compound [IDA]
- gamete generation [IMP]
- hindbrain development [IMP]
- homeostatic process [IMP]
- mesodermal cell fate commitment [IGI]
- midbrain development [IMP]
- negative regulation of cell proliferation [IMP]
- osteoblast fate commitment [IGI]
- positive regulation of cartilage development [IDA]
- positive regulation of cell differentiation [ISO]
- positive regulation of gene expression [IMP, ISO]
- positive regulation of osteoblast differentiation [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [IGI]
- protein phosphorylation [IDA]
- regulation of transcription from RNA polymerase II promoter [IDA]
- response to drug [ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- I-SMAD binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- co-SMAD binding [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA]
- protein kinase binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- I-SMAD binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- co-SMAD binding [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA]
- protein kinase binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Interaction of Smads with collagen types I, III, and V.
Ontogenesis of the mammalian orofacial region is controlled by numerous developmental signals, including those initiated by the transforming growth factors beta (TGFbetas). Targeted deletion of the genes encoding several of the TGFbetas in mice has been shown to result in clefts of the secondary palate. Members of the TGFbeta family of growth factors utilize intracellular Smads as signal transducers. Smads ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID