BAIT

VIF

HIV1gp3
p23
GO Process (0)
GO Function (0)
GO Component (0)
Human Immunodeficiency Virus 1
PREY

CAND1

TIP120, TIP120A
cullin-associated and neddylation-dissociated 1
UPS Project
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

HIV-1 Vif promotes the G₁- to S-phase cell-cycle transition.

Wang J, Reuschel EL, Shackelford JM, Jeang L, Shivers DK, Diehl JA, Yu XF, Finkel TH

HIV-1 depends on host-cell resources for replication, access to which may be limited to a particular phase of the cell cycle. The HIV-encoded proteins Vpr (viral protein R) and Vif (viral infectivity factor) arrest cells in the G₂ phase; however, alteration of other cell-cycle phases has not been reported. We show that Vif drives cells out of G₁ and into ... [more]

Blood Jan. 27, 2011; 117(4);1260-9 [Pubmed: 21149631]

Throughput

  • High Throughput

Curated By

  • BioGRID