BAIT
CFTR
ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1, tcag7.78
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
GO Process (9)
GO Function (9)
GO Component (10)
Gene Ontology Biological Process
- cellular response to cAMP [ISS]
- chloride transmembrane transport [IDA, ISS, NAS, TAS]
- intracellular pH elevation [ISS]
- membrane hyperpolarization [ISS]
- positive regulation of voltage-gated chloride channel activity [IDA]
- respiratory gaseous exchange [TAS]
- sperm capacitation [ISS]
- transmembrane transport [TAS]
- transport [TAS]
Gene Ontology Molecular Function- ATP-binding and phosphorylation-dependent chloride channel activity [TAS]
- PDZ domain binding [IDA]
- bicarbonate transmembrane transporter activity [ISS]
- channel-conductance-controlling ATPase activity [NAS]
- chloride channel activity [IDA]
- chloride channel inhibitor activity [IDA]
- chloride transmembrane transporter activity [ISS]
- enzyme binding [IPI]
- protein binding [IPI]
- ATP-binding and phosphorylation-dependent chloride channel activity [TAS]
- PDZ domain binding [IDA]
- bicarbonate transmembrane transporter activity [ISS]
- channel-conductance-controlling ATPase activity [NAS]
- chloride channel activity [IDA]
- chloride channel inhibitor activity [IDA]
- chloride transmembrane transporter activity [ISS]
- enzyme binding [IPI]
- protein binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
CAND1
TIP120, TIP120A
cullin-associated and neddylation-dissociated 1
GO Process (4)
GO Function (1)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.
The pathways that distinguish transport of folded and misfolded cargo through the exocytic (secretory) pathway of eukaryotic cells remain unknown. Using proteomics to assess global cystic fibrosis (CF) transmembrane conductance regulator (CFTR) protein interactions (the CFTR interactome), we show that Hsp90 cochaperones modulate Hsp90-dependent stability of CFTR protein folding in the endoplasmic reticulum (ER). Cell-surface rescue of the most common ... [more]
Cell Nov. 17, 2006; 127(4);803-15 [Pubmed: 17110338]
Throughput
- High Throughput
Ontology Terms
- cell line: colorectal adenocarcinoma cell line (BTO:0001914) [colorectal cancer (DOID:9256)]
Additional Notes
- T84 cell
Curated By
- BioGRID