BAIT
WWTR1
2310058J06Rik, 2610021I22Rik, C78399, Taz
WW domain containing transcription regulator 1
GO Process (24)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IMP]
- cilium morphogenesis [IMP]
- glomerulus development [IMP]
- hippo signaling [ISO]
- kidney morphogenesis [IMP]
- mesenchymal cell differentiation [IMP]
- multicellular organism growth [IMP]
- negative regulation of canonical Wnt signaling pathway [ISO]
- negative regulation of catenin import into nucleus [ISO]
- negative regulation of fat cell differentiation [IGI]
- negative regulation of protein kinase activity [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- osteoblast differentiation [IGI, IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of epithelial to mesenchymal transition [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- protein ubiquitination [IDA]
- regulation of SMAD protein import into nucleus [ISO]
- regulation of canonical Wnt signaling pathway [IGI]
- regulation of metanephric nephron tubule epithelial cell differentiation [IGI]
- regulation of nucleic acid-templated transcription [ISO]
- regulation of transcription, DNA-templated [IDA]
- stem cell division [ISO]
Gene Ontology Molecular Function
Mus musculus
PREY
MPP5
PALS1
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
GO Process (4)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway.
The Hippo pathway senses cell density information to control tissue growth by regulating the localization of the transcriptional regulators TAZ and YAP (TAZ/YAP). TAZ/YAP also regulate TGF-β-SMAD signaling, but whether this role is linked to cell density sensing is unknown. Here we demonstrate that TAZ/YAP dictate the localization of active SMAD complexes in response to cell density-mediated formation of polarity ... [more]
Dev. Cell Dec. 14, 2010; 19(6);831-44 [Pubmed: 21145499]
Throughput
- Low Throughput
Curated By
- BioGRID