Related Resources

BioGRID themed curation projects focus on specific biological processes with disease relevance. Core genes/proteins central to the process are assembled with expert input and relevant publications curated for biological interactions. Themed curation projects are updated monthly and additional projects are generated on a regular basis.

See current projects on COVID-19 Coronavirus, Fanconi Anemia, Glioblastoma, the Yeast Kinome, the Ubiquitin-Proteasome System and Autophagy. If you would like to suggest or participate in a new themed project, please contact biogridadmin@gmail.com

The BioGRID Open Respository of CRISPR Screens (ORCS) is a publicly accessible database of CRISPR screens compiled through comprehensive curation efforts.

GIX is a browser extension that allows you to retrieve information about a gene product directly on any webpage simply by double clicking an official gene name, synonym or supported accession.


Latest News

The BioGRID ORCS curated CRISPR database has been updated to include CRISPR screens from a total of 266 different publications. These additions bring the total number of curated CRISPR screens in our database to 1,592 encompassing 86,000+ genes, 745 different cell lines, 127 different cell types, and 23 different phenotypes across 4 different organisms (Human, Mouse, African Green Monkey, and Fruit Fly). Additionally, we've curated 53 coronavirus-related screens including 24 specifically for SARS-CoV-2 (COVID-19).

New curated data are added to our CRISPR Database in curation updates on a regular basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these CRISPR data, visit our download page or utilize our web service.

BioGRID ORCS Version 1.1.12 Released
Posted: May 4, 2022 - 3:47 am

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 79,845 publications. These additions bring our total number of non-redundant interactions to 1,920,021, raw interactions to 2,467,140, non-redundant chemical associations to 13,057, raw chemical associations to 29,417, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

BioGRID Version 4.4.209 Released
Posted: May 1, 2022 - 5:02 am

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 79,570 publications. These additions bring our total number of non-redundant interactions to 1,890,467, raw interactions to 2,424,838, non-redundant chemical associations to 13,057, raw chemical associations to 29,417, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

BioGRID Version 4.4.208 Released
Posted: April 2, 2022 - 3:32 am

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 79,457 publications. These additions bring our total number of non-redundant interactions to 1,878,962, raw interactions to 2,412,071, non-redundant chemical associations to 13,057, raw chemical associations to 29,417, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

BioGRID Version 4.4.207 Released
Posted: March 1, 2022 - 5:42 am

BioGRID themed curation projects focus on specific biological processes with disease relevance. Core genes/proteins central to the process are assembled with expert input and relevant publications curated for biological interactions. All BioGRID Themed curation projects are updated monthly and the following is a listing of our current themed curation projects, and their statistics as of this update:

Project Proteins Publications Interactions Chemical
Interactions
PTMs
COVID-19 Coronavirus 110 507 28,576 - 156
Ubiquitin-Proteasome System 1,586 21,628 336,522 1,875 62,580
Fanconi Anemia 69 3,407 21,154 100 4,530
Glioblastoma 198 6,521 39,025 882 8,771
Autophagy 197 4,069 39,755 334 7,461
Saccharomyces cerevisiae Kinome 260 5,244 100,897 - 3,861

To view all BioGRID Themed Curation Projects, visit our project page. For more information on BioGRID curation of themed projects or if you're interested in contributing to a new or existing project, please contact us at biogridadmin@gmail.com.

BioGRID Themed Curation Projects Update (4.4.206)
Posted: February 1, 2022 - 2:47 am

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 79,067 publications. These additions bring our total number of non-redundant interactions to 1,868,254, raw interactions to 2,398,355, non-redundant chemical associations to 13,057, raw chemical associations to 29,417, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

BioGRID Version 4.4.206 Released
Posted: February 1, 2022 - 1:19 am

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 78,774 publications. These additions bring our total number of non-redundant interactions to 1,864,111, raw interactions to 2,392,652, non-redundant chemical associations to 13,057, raw chemical associations to 29,417, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

BioGRID Version 4.4.205 Released
Posted: January 1, 2022 - 4:56 am

The BioGRID ORCS curated CRISPR database has been updated to include CRISPR screens from a total of 246 different publications. These additions bring the total number of curated CRISPR screens in our database to 1,514 encompassing 85,000+ genes, 736 different cell lines, 125 different cell types, and 23 different phenotypes across 4 different organisms (Human, Mouse, African Green Monkey, and Fruit Fly). Additionally, we've curated 52 coronavirus-related screens including 24 specifically for SARS-CoV-2 (COVID-19).

New curated data are added to our CRISPR Database in curation updates on a regular basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these CRISPR data, visit our download page or utilize our web service.

BioGRID ORCS Version 1.1.11 Released
Posted: December 25, 2021 - 3:47 am

BioGRID themed curation projects focus on specific biological processes with disease relevance. Core genes/proteins central to the process are assembled with expert input and relevant publications curated for biological interactions. All BioGRID Themed curation projects are updated monthly and the following is a listing of our current themed curation projects, and their statistics as of this update:

Project Proteins Publications Interactions Chemical
Interactions
PTMs
COVID-19 Coronavirus 110 473 28,423 - 156
Ubiquitin-Proteasome System 1,586 21,362 322,515 1,875 62,580
Fanconi Anemia 69 3,317 20,209 100 4,530
Glioblastoma 198 6,462 37,266 882 8,771
Autophagy 197 4,002 36,416 334 7,461
Saccharomyces cerevisiae Kinome 260 5,222 100,765 - 3,861

To view all BioGRID Themed Curation Projects, visit our project page. For more information on BioGRID curation of themed projects or if you're interested in contributing to a new or existing project, please contact us at biogridadmin@gmail.com.

BioGRID Themed Curation Projects Update (4.4.204)
Posted: December 10, 2021 - 2:49 pm

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 78,593 publications. These additions bring our total number of non-redundant interactions to 1,793,927, raw interactions to 2,306,028, non-redundant chemical associations to 13,057, raw chemical associations to 29,417, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

BioGRID Version 4.4.204 Released
Posted: December 1, 2021 - 1:16 am

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