Related Resources

The BioGRID Open Respository of CRISPR Screens (ORCS) is a publicly accessible database of CRISPR screens compiled through comprehensive curation of all genome-wide CRISPR screen data reported in the biomedical literature. ORCS is updated on a quarterly basis and is fully searchable by gene/protein, phenotype, cell line, authors, and other attributes. Each screen recorded in ORCS is accompanied by structured metadata annotation that captures salient CRISPR experimental details. All data in ORCS can be downloaded in standard formats.

BioGRID themed curation projects focus on specific biological processes with disease relevance. Core genes/proteins central to the process are assembled with expert input and relevant publications curated for biological interactions. Themed curation projects are updated monthly and additional projects are generated on a regular basis.

See current projects on COVID-19 Coronavirus, Fanconi Anemia, Glioblastoma, the Yeast Kinome, the Ubiquitin-Proteasome System and Autophagy. If you would like to suggest or participate in a new themed project, please contact biogridadmin@gmail.com

GIX is a browser extension that allows you to retrieve information about a gene product directly on any webpage simply by double clicking an official gene name, synonym or supported accession.


Latest News

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 81,004 publications. These additions bring our total number of non-redundant interactions to 1,979,529, raw interactions to 2,541,478, non-redundant chemical associations to 13,057, raw chemical associations to 29,417, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

BioGRID Version 4.4.214 Released
Posted: October 1, 2022 - 10:22 am

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 80,848 publications. These additions bring our total number of non-redundant interactions to 1,976,685, raw interactions to 2,537,592, non-redundant chemical associations to 13,057, raw chemical associations to 29,417, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

BioGRID Version 4.4.213 Released
Posted: September 1, 2022 - 10:11 am

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 80,728 publications. These additions bring our total number of non-redundant interactions to 1,940,092, raw interactions to 2,493,370, non-redundant chemical associations to 13,057, raw chemical associations to 29,417, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

BioGRID Version 4.4.212 Released
Posted: August 1, 2022 - 5:02 am

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 80,396 publications. These additions bring our total number of non-redundant interactions to 1,934,324, raw interactions to 2,485,937, non-redundant chemical associations to 13,057, raw chemical associations to 29,417, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

BioGRID Version 4.4.211 Released
Posted: July 1, 2022 - 8:52 am

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 80,097 publications. These additions bring our total number of non-redundant interactions to 1,926,299, raw interactions to 2,475,167, non-redundant chemical associations to 13,057, raw chemical associations to 29,417, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

BioGRID Version 4.4.210 Released
Posted: June 1, 2022 - 7:22 am

The BioGRID ORCS curated CRISPR database has been updated to include CRISPR screens from a total of 266 different publications. These additions bring the total number of curated CRISPR screens in our database to 1,592 encompassing 86,000+ genes, 745 different cell lines, 127 different cell types, and 23 different phenotypes across 4 different organisms (Human, Mouse, African Green Monkey, and Fruit Fly). Additionally, we've curated 53 coronavirus-related screens including 24 specifically for SARS-CoV-2 (COVID-19).

New curated data are added to our CRISPR Database in curation updates on a regular basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these CRISPR data, visit our download page or utilize our web service.

BioGRID ORCS Version 1.1.12 Released
Posted: May 4, 2022 - 3:47 am

The BioGRID ORCS curated CRISPR database has been updated to include CRISPR screens from a total of 282 different publications. These additions bring the total number of curated CRISPR screens in our database to 1,678 encompassing 93,000+ genes, 764 different cell lines, 129 different cell types, and 23 different phenotypes across 5 different organisms (Budding Yeast, Human, Mouse, African Green Monkey, and Fruit Fly). Additionally, we've curated 87 coronavirus-related screens including 52 specifically for SARS-CoV-2 (COVID-19).

New curated data are added to our CRISPR Database in curation updates on a regular basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these CRISPR data, visit our download page or utilize our web service.

BioGRID ORCS Version 1.1.13 Released
Posted: May 4, 2022 - 3:47 am

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 79,845 publications. These additions bring our total number of non-redundant interactions to 1,920,021, raw interactions to 2,467,140, non-redundant chemical associations to 13,057, raw chemical associations to 29,417, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

BioGRID Version 4.4.209 Released
Posted: May 1, 2022 - 5:02 am

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 79,570 publications. These additions bring our total number of non-redundant interactions to 1,890,467, raw interactions to 2,424,838, non-redundant chemical associations to 13,057, raw chemical associations to 29,417, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

BioGRID Version 4.4.208 Released
Posted: April 2, 2022 - 3:32 am

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 79,457 publications. These additions bring our total number of non-redundant interactions to 1,878,962, raw interactions to 2,412,071, non-redundant chemical associations to 13,057, raw chemical associations to 29,417, Non-Redundant PTM Sites to 563,757 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

BioGRID Version 4.4.207 Released
Posted: March 1, 2022 - 5:42 am

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National Institutes of Health National Institutes of Health - Office of Research Infrastructure Programs Canadian Institutes of Health Research Mount Sinai Hospital Toronto Princeton University Universite de Montreal

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