Related Resources

The BioGRID Open Respository of CRISPR Screens (ORCS) is a publicly accessible database of CRISPR screens compiled through comprehensive curation efforts.

GIX is a browser extension that allows you to retrieve information about a gene product directly on any webpage simply by double clicking an official gene name, synonym or supported accession.

This BioGRID project page is designed to allow exploration of the entire yeast kinome and its interactions, including genetic interactions and all mapped sites of protein phosphorylation.


Latest News

The BioGRID ORCS curated CRISPR database has been updated to include CRISPR screens from a total of 86 different publications. These additions bring our total number of curated CRISPR screens in our database to 987 encompassing 59,300+ genes, 657 different cell lines, 105 different cell types, and 15 different phenotypes across 3 different organisms (Human, Mouse, and Fruit Fly).

New curated data are added to our CRISPR Database in curation updates on a regular basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these CRISPR data, visit our download page or utilize our web service.

Posted: August 7, 2020 - 10:07 pm

COVID-19 is a rapidly evolving global health crisis and BioGRID is expediting release of new datasets for SARS-CoV-2, SARS-CoV, and MERS-CoV to help facilitate new therapeutic approaches. The BioGRID's curated set of Coronavirus-related data have been updated to include interactions from 143 publications and preliminary reports. These additions bring our total number of Coronavirus-related interactions to 3,429 including 2,177 interactions from 45 publications and preliminary reports for SARS-CoV-2 (COVID-19). To download all coronavirus-related interaction data in BioGRID, visit our download page. For more information on BioGRID curation of SARS-CoV-2 (COVID-19) and related Coronaviruses, check out our wiki.

If you have interaction data for SARS-CoV-2 (or other Coronavirus-related data) that you'd like to deposit directly into the BioGRID Database, please contact us at biogridadmin@gmail.com.

BioGRID Build 3.5.188 includes 3,429 Coronavirus-related Interactions
Posted: August 1, 2020 - 5:44 am

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 72,826 publications. These additions bring our total number of non-redundant interactions to 1,472,343, raw interactions to 1,881,423, non-redundant chemical associations to 12,015, raw chemical associations to 28,093, Non-Redundant PTM Sites to 458,181, Raw PTM Sites to 817,400 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: August 1, 2020 - 4:57 am

COVID-19 is a rapidly evolving global health crisis and BioGRID is expediting release of new datasets for SARS-CoV-2, SARS-CoV, and MERS-CoV to help facilitate new therapeutic approaches. The BioGRID's curated set of Coronavirus-related data have been updated to include interactions from 142 publications and preliminary reports. These additions bring our total number of Coronavirus-related interactions to 2,796 including 1,546 interactions from 44 publications and preliminary reports for SARS-CoV-2 (COVID-19). To download all coronavirus-related interaction data in BioGRID, visit our download page. For more information on BioGRID curation of SARS-CoV-2 (COVID-19) and related Coronaviruses, check out our wiki.

If you have interaction data for SARS-CoV-2 (or other Coronavirus-related data) that you'd like to deposit directly into the BioGRID Database, please contact us at biogridadmin@gmail.com.

BioGRID Build 3.5.187 includes 2,796 Coronavirus-related Interactions
Posted: July 1, 2020 - 6:11 am

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 72,637 publications. These additions bring our total number of non-redundant interactions to 1,469,992, raw interactions to 1,878,317, non-redundant chemical associations to 12,015, raw chemical associations to 28,093, Non-Redundant PTM Sites to 458,181, Raw PTM Sites to 817,400 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: July 1, 2020 - 3:24 am

The latest update of BioGRID (build 3.5.186) adds 52,000+ new human two-hybrid interactions from the study "A reference map of the human binary protein interactome" by Luck K et al (Nature, April 2020). This human reference interactome (HuRI) contains high throughput protein interactions that may be integrated with genome, transcriptome and proteome data in order to study the function of proteins within different physiological and pathological cellular contexts. The data for this publication can also be accessed and downloaded online at the The Human Reference Protein Interactome Mapping Project.

A special thanks to all authors of the study: Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG, Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF, Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC, Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A, Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG, Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S, Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A, Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S, Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli D, Sheynkman GM, Simonovsky E, Ta?an M, Tejeda A, Tropepe V, Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X, Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S, Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood MA

If you have interaction data you'd like to deposit directly into the BioGRID Database, please contact us at biogridadmin@gmail.com.

Featured Dataset: 52,000+ new Two-Hybrid interactions for Human from Luck K et al. (2020)
Posted: June 17, 2020 - 11:47 am

The latest update of BioGRID (build 3.5.186) adds 27,000+ new mouse co-fractionation interactions from the study "BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain" by Pourhaghighi R et al (Cell Syst., April 2020). To elucidate the protein interactions underlying normal neuron function in the mammalian brain, the authors performed a comprehensive multi-dimensional biochemical fractionation assay, surveying endogenous macromolecules across the adult mouse brain and providing a global interactome.

A special thanks to all authors of the study: Pourhaghighi R, Ash PEA, Phanse S, Goebels F, Hu LZM, Chen S, Zhang Y, Wierbowski SD, Boudeau S, Moutaoufik MT, Malty RH, Malolepsza E, Tsafou K, Nathan A, Cromar G, Guo H, Abdullatif AA, Apicco DJ, Becker LA, Gitler AD, Pulst SM, Youssef A, Hekman R, Havugimana PC, White CA, Blum BC, Ratti A, Bryant CD, Parkinson J, Lage K, Babu M, Yu H, Bader GD, Wolozin B, and Emili A

If you have interaction data you'd like to deposit directly into the BioGRID Database, please contact us at biogridadmin@gmail.com.

Featured Dataset: 27,000+ new co-fractionation interactions for mouse from Pourhaghighi R et al. (2020)
Posted: June 4, 2020 - 2:08 pm

COVID-19 is a rapidly evolving global health crisis and BioGRID is expediting release of new datasets for SARS-CoV-2, SARS-CoV, and MERS-CoV to help facilitate new therapeutic approaches. The BioGRID's curated set of Coronavirus-related data have been updated to include interactions from 123 publications and preliminary reports. These additions bring our total number of Coronavirus-related interactions to 967 including 414 interactions from 36 publications and preliminary reports for SARS-CoV-2 (COVID-19). To download all coronavirus-related interaction data in BioGRID, visit our download page. For more information on BioGRID curation of SARS-CoV-2 (COVID-19) and related Coronaviruses, check out our wiki.

If you have interaction data for SARS-CoV-2 (or other Coronavirus-related data) that you'd like to deposit directly into the BioGRID Database, please contact us at biogridadmin@gmail.com.

BioGRID Build 3.5.186 includes 967 Coronavirus-related Interactions
Posted: June 1, 2020 - 12:12 pm

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 72,408 publications. These additions bring our total number of non-redundant interactions to 1,464,100, raw interactions to 1,871,024, non-redundant chemical associations to 12,015, raw chemical associations to 28,093, Non-Redundant PTM Sites to 458,181, Raw PTM Sites to 817,400 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: June 1, 2020 - 4:04 am

BioGRID update 3.5.185 includes a comprehensive update to our Schizosaccharomyces pombe dataset in partnership with The Scientific Resource for Fission Yeast (PomBase). This update incorporates more than 900 new interactions. Moreover, this increases the total number of Schizosaccharomyces pombe interactions deposited in BioGRID to 79,863 from 2,874 publications. These interactions and all associated meta data are available immediately online via all standard BioGRID searches and supported download formats. You can also find these and many additional fission yeast resources available at https://www.pombase.org.

A special thanks to the PomBase Team for their tireless curation efforts and in particular Antonia Lock, Kim Rutherford and Valerie Wood for directly helping to facilitate the BioGRID collaboration.

If you have an interaction dataset you'd like to deposit directly into the BioGRID, please contact us at biogridadmin@gmail.com.

Comprehensive Schizosaccharomyces pombe update from PomBase includes 900+ New Interactions
Posted: May 19, 2020 - 3:16 am

Partners

National Institutes of Health National Institutes of Health - Office of Research Infrastructure Programs Canadian Institutes of Health Research Mount Sinai Hospital Toronto Princeton University Universite de Montreal

Latest Updates