Related Resources

The BioGRID Open Respository of CRISPR Screens (ORCS) is a publicly accessible database of CRISPR screens compiled through comprehensive curation efforts.

This BioGRID project page is designed to allow exploration of the entire yeast kinome and its interactions, including genetic interactions and all mapped sites of protein phosphorylation.

GIX is a browser extension that allows you to retrieve information about a gene product directly on any webpage simply by double clicking an official gene name, synonym or supported accession.


Latest News

COVID-19 is a rapidly evolving global health crisis and BioGRID is expediting release of new datasets for SARS-CoV-2, SARS-CoV, and MERS-CoV to help facilitate new therapeutic approaches. The BioGRID COVID-19 Coronavirus Project has been updated to include interactions from 175 publications and preliminary reports. These additions bring our total number of Coronavirus-related interactions to 3,502 including 2,266 interactions from 81 publications and preliminary reports for SARS-CoV-2 (COVID-19). To download all coronavirus-related interaction data in BioGRID, visit our download page. For more information on BioGRID curation of SARS-CoV-2 (COVID-19) and related Coronaviruses, check out the COVID-19 Coronavirus Project page.

If you have interaction data for SARS-CoV-2 (or other Coronavirus-related data) that you'd like to deposit directly into the BioGRID Database, please contact us at biogridadmin@gmail.com.

BioGRID Build 4.0.189 includes 3,502 Coronavirus-related Interactions
Posted: September 1, 2020 - 5:44 am

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 73,056 publications. These additions bring our total number of non-redundant interactions to 1,480,737, raw interactions to 1,891,411, non-redundant chemical associations to 12,015, raw chemical associations to 28,093, Non-Redundant PTM Sites to 458,181, Raw PTM Sites to 817,400 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: September 1, 2020 - 3:16 am

Our latest BioGRID ORCS CRISPR Database update adds a new screen from the study, "Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP-ribosyltransferase PARP14 in DNA replication dynamics controlled by ATR" by Dhoonmoon A et al. (Nucleic Acids Res, 2020). For this dataset, a genome-wide CRISPR knockout screen was carried out in PARP14-deficient cells identifying synthetic lethal interactors of PARP14, including several components of the ATR DNA replication stress pathway. The ATR-CHK1 pathway was found to be essential for viability of PARP14-deficient cells. This indicates that the status of the PARP14 gene in a tumor may be an important determinant of its response to DNA damage response (DDR)inhibitors, such as ATR–CHK1 pathway inhibitors which are being developed as anti-cancer drugs.

A special thanks to the authors Dhoonmoon A, Schleicher EM, Clements KE, Nicolae CM and Moldovan GL and the Department of Biochemistry & Molecular Biology at PennState. We'd also like to specifically thank author George-Lucian Moldovan for working with us to ensure this dataset was deposited directly into our CRISPR Database.

If you have a CRISPR Screen Dataset you'd like to deposit directly into the BioGRID ORCS CRISPR Database, please contact us at biogridadmin@gmail.com.

Featured Dataset: A new Human CRISPR-Cas9 Screen Exploring Essential Genes in PARP14-deficient Cells from Dhoonmoon A et. al (2020)
Posted: August 18, 2020 - 2:19 pm

Our latest BioGRID Featured Dataset added 6,400+ new human co-fractionation interactions from the study "Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis" by Moutaoufik MT et al (iScience, Sept. 2019). This study provides an experimentally derived catalog of protein interactions between over 600 mitochondrial proteins. These interactions can help reveal functions for uncharacterized genes, as seen for C20orf24.

A special thanks to all authors of the study: Moutaoufik MT, Malty R, Amin S, Zhang Q, Phanse S, Gagarinova A, Zilocchi M, Hoell L, Minic Z, Gagarinova M, Aoki H, Stockwell J, Jessulat M, Goebels F, Broderick K, Scott NE, Vlasblom J, Musso G, Prasad B, Lamantea E, Garavaglia B, Rajput A, Murayama K, Okazaki Y, Foster LJ, Bader GD, Cayabyab FS and Babu M

If you have interaction data you'd like to deposit directly into the BioGRID Database, please contact us at biogridadmin@gmail.com.

Featured Dataset: 6,400+ Co-fractionation Interactions for Human from Moutaoufik MT et al. (2020)
Posted: August 14, 2020 - 1:12 pm

The BioGRID ORCS curated CRISPR database has been updated to include CRISPR screens from a total of 86 different publications. These additions bring our total number of curated CRISPR screens in our database to 987 encompassing 59,300+ genes, 657 different cell lines, 105 different cell types, and 15 different phenotypes across 3 different organisms (Human, Mouse, and Fruit Fly).

New curated data are added to our CRISPR Database in curation updates on a regular basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these CRISPR data, visit our download page or utilize our web service.

Posted: August 7, 2020 - 10:07 pm

COVID-19 is a rapidly evolving global health crisis and BioGRID is expediting release of new datasets for SARS-CoV-2, SARS-CoV, and MERS-CoV to help facilitate new therapeutic approaches. The BioGRID's curated set of Coronavirus-related data have been updated to include interactions from 143 publications and preliminary reports. These additions bring our total number of Coronavirus-related interactions to 3,429 including 2,177 interactions from 45 publications and preliminary reports for SARS-CoV-2 (COVID-19). To download all coronavirus-related interaction data in BioGRID, visit our download page. For more information on BioGRID curation of SARS-CoV-2 (COVID-19) and related Coronaviruses, check out our wiki.

If you have interaction data for SARS-CoV-2 (or other Coronavirus-related data) that you'd like to deposit directly into the BioGRID Database, please contact us at biogridadmin@gmail.com.

BioGRID Build 3.5.188 includes 3,429 Coronavirus-related Interactions
Posted: August 1, 2020 - 5:44 am

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 72,826 publications. These additions bring our total number of non-redundant interactions to 1,472,343, raw interactions to 1,881,423, non-redundant chemical associations to 12,015, raw chemical associations to 28,093, Non-Redundant PTM Sites to 458,181, Raw PTM Sites to 817,400 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: August 1, 2020 - 4:57 am

COVID-19 is a rapidly evolving global health crisis and BioGRID is expediting release of new datasets for SARS-CoV-2, SARS-CoV, and MERS-CoV to help facilitate new therapeutic approaches. The BioGRID's curated set of Coronavirus-related data have been updated to include interactions from 142 publications and preliminary reports. These additions bring our total number of Coronavirus-related interactions to 2,796 including 1,546 interactions from 44 publications and preliminary reports for SARS-CoV-2 (COVID-19). To download all coronavirus-related interaction data in BioGRID, visit our download page. For more information on BioGRID curation of SARS-CoV-2 (COVID-19) and related Coronaviruses, check out our wiki.

If you have interaction data for SARS-CoV-2 (or other Coronavirus-related data) that you'd like to deposit directly into the BioGRID Database, please contact us at biogridadmin@gmail.com.

BioGRID Build 3.5.187 includes 2,796 Coronavirus-related Interactions
Posted: July 1, 2020 - 6:11 am

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 72,637 publications. These additions bring our total number of non-redundant interactions to 1,469,992, raw interactions to 1,878,317, non-redundant chemical associations to 12,015, raw chemical associations to 28,093, Non-Redundant PTM Sites to 458,181, Raw PTM Sites to 817,400 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: July 1, 2020 - 3:24 am

The latest update of BioGRID (build 3.5.186) adds 52,000+ new human two-hybrid interactions from the study "A reference map of the human binary protein interactome" by Luck K et al (Nature, April 2020). This human reference interactome (HuRI) contains high throughput protein interactions that may be integrated with genome, transcriptome and proteome data in order to study the function of proteins within different physiological and pathological cellular contexts. The data for this publication can also be accessed and downloaded online at the The Human Reference Protein Interactome Mapping Project.

A special thanks to all authors of the study: Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG, Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF, Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC, Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A, Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG, Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S, Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A, Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S, Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli D, Sheynkman GM, Simonovsky E, Ta?an M, Tejeda A, Tropepe V, Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X, Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S, Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood MA

If you have interaction data you'd like to deposit directly into the BioGRID Database, please contact us at biogridadmin@gmail.com.

Featured Dataset: 52,000+ new Two-Hybrid interactions for Human from Luck K et al. (2020)
Posted: June 17, 2020 - 11:47 am

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