Related Resources

The BioGRID Open Respository of CRISPR Screens (ORCS) is a publicly accessible database of CRISPR screens compiled through comprehensive curation efforts.

GIX is a browser extension that allows you to retrieve information about a gene product directly on any webpage simply by double clicking an official gene name, synonym or supported accession.

This BioGRID project page is designed to allow exploration of the entire yeast kinome and its interactions, including genetic interactions and all mapped sites of protein phosphorylation.


Latest News

COVID-19 is a rapidly evolving global health crisis and the research community is expediting release of new pre-publication datasets on SARS-CoV-2 to facilitate new therapeutic approaches. The latest update of BioGRID (build 3.5.183) adds 332 new SARS-CoV-2 affinity capture-MS interactions from the study "A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing" by Gordon et al (Pre-Publication, bioRxiv, 2020). This study reports the systematic interrogation of 27 ORFs encoded by SARS-CoV-2 for protein interactions with human host proteins and suggests many candidate drugs for repurposing against viral targets.

A special thanks to David Gordon and Nevan Krogan for providing data in advance of release, and thanks to all authors of the study: Gordon DE, Jang G, Bouhaddou M, Xu J, Obernier K, O'Meara M, Guo J, Swaney D, Tummino T, Huettenhain R, Kaake R, Richards A, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco B, Braberg H, Fabius J, Eckhardt M, Soucheray M, Bennett M, Cakir M, McGregor M, Li Q, Naing Z, Zhou Y, Peng S, Kirby I, Melnyk J, Chorba J, Lou K, Dai S, Shen W, Shi Y, Zhang Z, Barrio-Hernandez I, Danish Memon D, Hernandez-Armenta C, Mathy C, Perica T, Pilla K, Ganesan S, Saltzberg D, Ramachandran R, Liu X, Rosenthal S, Calviello L, Venkataramanan S, LiboyLugo J, Lin Y, Wankowicz S, Bohn M, Sharp P, Trenker R, Young J, Cavero D, Hiatt J, Roth T, Rathore U, Subramanian A, Noack J, Hubert M, Roesch F, Vallet T, Meyer B, White K, Miorin L, Rosenberg O, Verba K, Agard D, Ott M, Emerman M, Ruggero D, Garcia-Sastre A, Jura N, Zastrow M, Taunton J, Schwartz O, Vignuzzi M, Enfert C, Mukherjee S, Jacobson M, Malik H, Fujimori D, Ideker T, Craik C, Floor S, Fraser J, Gross J, Sali A, Kortemme T, Beltrao P, Shokat K, Shoichet B, and Krogan J.

If you have interaction data for SARS-CoV-2 that you'd like to deposit directly into the BioGRID Database, please contact us at biogridadmin@gmail.com.

BioGRID Build 3.5.183 adds 332 new affinity capture-MS interactions for SARS-CoV-2 from Gordon DE et al. (2020)
Posted: March 29, 2020 - 2:38 pm

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 71,871 publications. These additions bring our total number of non-redundant interactions to 1,382,485, raw interactions to 1,778,635, non-redundant chemical associations to 12,015, raw chemical associations to 28,093, Non-Redundant PTM Sites to 458,181, Raw PTM Sites to 817,400 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: March 28, 2020 - 2:53 am

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 71,713 publications. These additions bring our total number of non-redundant interactions to 1,376,369, raw interactions to 1,771,685, non-redundant chemical associations to 12,015, raw chemical associations to 28,093, Non-Redundant PTM Sites to 458,181, Raw PTM Sites to 817,400 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: March 1, 2020 - 2:09 am

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 71,559 publications. These additions bring our total number of non-redundant interactions to 1,376,013, raw interactions to 1,770,514, non-redundant chemical associations to 12,015, raw chemical associations to 28,093, Non-Redundant PTM Sites to 458,181, Raw PTM Sites to 817,400 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: February 1, 2020 - 5:49 am

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 71,342 publications. These additions bring our total number of non-redundant interactions to 1,369,855, raw interactions to 1,763,194, non-redundant chemical associations to 12,015, raw chemical associations to 28,093, Non-Redundant PTM Sites to 458,181, Raw PTM Sites to 817,400 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: January 1, 2020 - 2:17 am

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 71,178 publications. These additions bring our total number of non-redundant interactions to 1,361,694, raw interactions to 1,753,686, non-redundant chemical associations to 12,015, raw chemical associations to 28,093, Non-Redundant PTM Sites to 458,181, Raw PTM Sites to 817,400 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: December 1, 2019 - 1:08 am

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 70,958 publications. These additions bring our total number of non-redundant interactions to 1,355,957, raw interactions to 1,746,922, non-redundant chemical associations to 12,015, raw chemical associations to 28,093, Non-Redundant PTM Sites to 458,181, Raw PTM Sites to 817,400 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: November 1, 2019 - 4:45 am

BioGRID ORCS build 1.0.3 (our latest update) added nearly 400 new screens to our CRISPR database including 325 from our latest featured dataset, "Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens." by Behan FM et al. (Nature, 2019). This comprehensive dataset is comprised of genome-scale CRISPR-Cas9 screens in 324 human cancer cell lines from 30 cancer types, and is developed to prioritize candidates for cancer therapeutics.

A special thanks to the authors Behan FM, Iorio F, Picco G, Gonçalves E, Beaver CM, Migliardi G, Santos R, Rao Y, Sassi F, Pinnelli M, Ansari R, Harper S, Jackson DA, McRae R, Pooley R, Wilkinson P, van der Meer D, Dow D, Buser-Doepner C, Bertotti A, Trusolino L, Stronach EA, Saez-Rodriguez J, Yusa K, and Garnett MJ and the Garnett Group, Yusa Group, Saez Lab, Heidelberg University, Open Targets, and the Wellcome Sanger Institute.

If you have a CRISPR Screen Dataset you'd like to deposit directly into the BioGRID ORCS CRISPR Database, please contact us at biogridadmin@gmail.com.

BioGRID ORCS Build 1.0.3 added 325 new CRISPR-Cas9 screens for cancer therapeutic targets from Behan FM et al. (2019)
Posted: October 11, 2019 - 2:38 pm

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 70,715 publications. These additions bring our total number of non-redundant interactions to 1,350,574, raw interactions to 1,740,143, non-redundant chemical associations to 12,015, raw chemical associations to 28,093, Non-Redundant PTM Sites to 458,181, Raw PTM Sites to 817,400 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: October 1, 2019 - 5:54 am

The BioGRID's curated set of data have been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 70,417 publications. These additions bring our total number of non-redundant interactions to 1,345,800, raw interactions to 1,732,644, non-redundant chemical associations to 12,015, raw chemical associations to 28,093, Non-Redundant PTM Sites to 458,181, Raw PTM Sites to 817,400 and Un-Assigned PTMs to 57,396.

New curated data are added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest statistics. To download these data, visit our download page or utilize our web service.

Posted: September 1, 2019 - 4:45 am

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