A PDR5-independent pathway of multi-drug resistance regulated by the SIN4 gene product.
The SIN4 locus encodes a global transcriptional regulator of various yeast genes. In this report, we demonstrate that loss of function mutations in SIN4 create a multi-drug hypersensitive phenotype that is independent of PDR5 mediated resistance. Thus, double sin4, pdr5 mutants are more sensitive than single mutants. Furthermore, SIN4 does ... not regulate the PDR5 locus. These observations establish that yeast cells have two genetically distinct pathways conferring resistance towards similar substrates.
Mesh Terms:
ATP-Binding Cassette Transporters, Antifungal Agents, Clotrimazole, Cycloheximide, Drug Resistance, Microbial, Drug Resistance, Multiple, Fungal Proteins, Gene Expression Regulation, Fungal, Genes, Fungal, Mediator Complex, Membrane Proteins, Recombinant Fusion Proteins, Saccharomyces cerevisiae Proteins, Trans-Activators, Transcription, Genetic, Yeasts
ATP-Binding Cassette Transporters, Antifungal Agents, Clotrimazole, Cycloheximide, Drug Resistance, Microbial, Drug Resistance, Multiple, Fungal Proteins, Gene Expression Regulation, Fungal, Genes, Fungal, Mediator Complex, Membrane Proteins, Recombinant Fusion Proteins, Saccharomyces cerevisiae Proteins, Trans-Activators, Transcription, Genetic, Yeasts
Yeast
Date: Jan. 30, 1999
PubMed ID: 10029991
View in: Pubmed Google Scholar
Download Curated Data For This Publication
15152
Switch View:
- Interactions 1