BAIT
CLNK
MIST
cytokine-dependent hematopoietic cell linker
GO Process (3)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ARAP3
CENTD3, DRAG1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
GO Process (7)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- cytoskeleton organization [TAS]
- negative regulation of Rho protein signal transduction [ISS]
- negative regulation of cell migration [ISS]
- regulation of cell shape [ISS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Phospho-tyrosine dependent protein-protein interaction network.
Post-translational protein modifications, such as tyrosine phosphorylation, regulate protein-protein interactions (PPIs) critical for signal processing and cellular phenotypes. We extended an established yeast two-hybrid system employing human protein kinases for the analyses of phospho-tyrosine (pY)-dependent PPIs in a direct experimental, large-scale approach. We identified 292 mostly novel pY-dependent PPIs which showed high specificity with respect to kinases and interacting proteins ... [more]
Mol. Syst. Biol. Mar. 01, 2015; 11(3);794 [Pubmed: 25814554]
Throughput
- High Throughput
Additional Notes
- phospho-tyrosine dependent, interaction occurs in the presence of a kinase
Curated By
- BioGRID