BAIT
CLNK
MIST
cytokine-dependent hematopoietic cell linker
GO Process (3)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TXK
BTKL, PSCTK5, PTK4, RLK, TKL
TXK tyrosine kinase
GO Process (15)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- B cell receptor signaling pathway [IBA]
- T cell differentiation [IBA]
- T cell receptor signaling pathway [IBA, ISS]
- activation of phospholipase C activity [ISS]
- adaptive immune response [IBA, ISS]
- cytokine production [ISS]
- peptidyl-tyrosine autophosphorylation [IBA]
- positive regulation of interferon-gamma production [IDA]
- positive regulation of interferon-gamma-mediated signaling pathway [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein autophosphorylation [IDA]
- protein phosphorylation [TAS]
- regulation of cell proliferation [IBA]
- regulation of transcription from RNA polymerase II promoter [IDA]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II regulatory region DNA binding [IDA]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- protein binding [IPI]
- receptor binding [IBA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II regulatory region DNA binding [IDA]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- protein binding [IPI]
- receptor binding [IBA]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Phospho-tyrosine dependent protein-protein interaction network.
Post-translational protein modifications, such as tyrosine phosphorylation, regulate protein-protein interactions (PPIs) critical for signal processing and cellular phenotypes. We extended an established yeast two-hybrid system employing human protein kinases for the analyses of phospho-tyrosine (pY)-dependent PPIs in a direct experimental, large-scale approach. We identified 292 mostly novel pY-dependent PPIs which showed high specificity with respect to kinases and interacting proteins ... [more]
Mol. Syst. Biol. Mar. 01, 2015; 11(3);794 [Pubmed: 25814554]
Throughput
- High Throughput
Curated By
- BioGRID