BAIT
YAP1
PAR1, SNQ3, DNA-binding transcription factor YAP1, L000001364, YML007W
Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; relative distribution to the nucleus increases upon DNA replication stress; YAP1 has a paralog, CAD1, that arose from the whole genome duplication
GO Process (6)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance [IMP]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IDA]
- response to drug [IMP]
- response to heat [IMP]
- response to metal ion [IMP]
- response to singlet oxygen [IMP]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
PREY
PDR5
LEM1, STS1, YDR1, ATP-binding cassette multidrug transporter PDR5, L000001365, L000002136, L000002504, YOR153W
Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth; PDR5 has a paralog, PDR15, that arose from the whole genome duplication
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Fungicide Xylaria sp. BCC 1067 extract induces reactive oxygen species and activates multidrug resistance system in Saccharomyces cerevisiae.
To investigate antifungal potential of Xylaria sp. BIOTEC culture collection (BCC) 1067 extract against the model yeast Saccharomyces cerevisiae.Antifungal property of extract, reactive oxygen species levels and cell survival were determined, using selected deletion strains.Extract showed promising antifungal effect with minimal inhibitory concentration100 and minimal fungicidal concentration of 500 and 1000 mg/l, respectively. Strong synergy was observed with fractional inhibitory ... [more]
Future Microbiol Mar. 31, 2017; 0(); [Pubmed: 28361556]
Throughput
- Low Throughput
Ontology Terms
- vegetative growth (APO:0000106)
Additional Notes
- Xylaria extract
Curated By
- BioGRID