PMAIP1
Gene Ontology Biological Process
- T cell homeostasis [ISS]
- apoptotic process [IMP, TAS]
- cellular response to glucose starvation [IMP]
- cellular response to hypoxia [IEP]
- defense response to virus [IDA]
- intrinsic apoptotic signaling pathway [IDA, TAS]
- intrinsic apoptotic signaling pathway by p53 class mediator [IMP]
- negative regulation of mitochondrial membrane potential [ISS]
- positive regulation of DNA damage response, signal transduction by p53 class mediator [IMP]
- positive regulation of apoptotic process [IDA, IMP]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- positive regulation of glucose metabolic process [IDA]
- positive regulation of intrinsic apoptotic signaling pathway [IDA, TAS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- positive regulation of protein oligomerization [IDA]
- positive regulation of release of cytochrome c from mitochondria [IDA, IMP]
- proteasomal protein catabolic process [IDA]
- reactive oxygen species metabolic process [IDA]
- regulation of mitochondrial membrane permeability [IDA]
- response to dsRNA [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BAX
Gene Ontology Biological Process
- B cell apoptotic process [IDA]
- B cell receptor apoptotic signaling pathway [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA, IMP]
- activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [IDA]
- apoptotic mitochondrial changes [IDA]
- apoptotic process [NAS, TAS]
- apoptotic signaling pathway [IDA]
- endoplasmic reticulum calcium ion homeostasis [TAS]
- establishment or maintenance of transmembrane electrochemical gradient [IDA]
- extrinsic apoptotic signaling pathway [IDA]
- extrinsic apoptotic signaling pathway in absence of ligand [IBA]
- extrinsic apoptotic signaling pathway via death domain receptors [IC]
- intrinsic apoptotic signaling pathway [IDA, TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage [IBA]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IMP]
- mitochondrial fragmentation involved in apoptotic process [IDA]
- mitochondrial fusion [IDA]
- negative regulation of protein binding [IDA]
- positive regulation of apoptotic DNA fragmentation [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of endoplasmic reticulum unfolded protein response [IMP]
- positive regulation of intrinsic apoptotic signaling pathway [IMP]
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [TAS]
- positive regulation of neuron apoptotic process [IDA]
- positive regulation of protein oligomerization [IDA]
- positive regulation of release of cytochrome c from mitochondria [IDA]
- protein homooligomerization [IDA]
- protein oligomerization [IDA]
- regulation of mitochondrial membrane potential [IDA]
- regulation of protein heterodimerization activity [IPI]
- regulation of protein homodimerization activity [IDA]
- release of cytochrome c from mitochondria [IDA]
- release of matrix enzymes from mitochondria [IDA]
- response to toxic substance [IDA]
- retinal cell apoptotic process [IMP]
- transformed cell apoptotic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- BAX complex [IDA]
- Bcl-2 family protein complex [IDA]
- cytosol [IDA, TAS]
- endoplasmic reticulum [IDA]
- endoplasmic reticulum membrane [IDA]
- extracellular vesicular exosome [IDA]
- membrane [IDA]
- mitochondrial outer membrane [IBA, TAS]
- mitochondrial permeability transition pore complex [IDA]
- mitochondrion [IDA]
- nuclear envelope [IDA]
- nucleus [IDA, IMP]
- pore complex [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection.
Double-stranded RNA (dsRNA) accumulates in virally infected cells, leading to induction of genes encoding proteins involved in signaling, apoptosis, protein synthesis/processing, and cell metabolism. Noxa is a BH3-containing mitochondrial protein that contributes to apoptosis by disrupting mitochondrial outer membrane integrity. Here we demonstrate potent induction of Noxa expression by exposure of cells to dsRNA, interferon (IFN), and virus. Noxa induction ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID