BCL2
Gene Ontology Biological Process
- B cell proliferation [IDA]
- B cell receptor signaling pathway [IMP]
- apoptotic process [IDA, TAS]
- cellular response to DNA damage stimulus [IMP]
- defense response to virus [IDA]
- endoplasmic reticulum calcium ion homeostasis [TAS]
- extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- female pregnancy [NAS]
- humoral immune response [TAS]
- innate immune response [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage [IBA]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IDA]
- negative regulation of anoikis [IMP]
- negative regulation of apoptotic process [IDA, IMP]
- negative regulation of apoptotic signaling pathway [IMP]
- negative regulation of autophagy [TAS]
- negative regulation of cellular pH reduction [IDA]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IGI]
- negative regulation of intrinsic apoptotic signaling pathway [IDA]
- negative regulation of mitochondrial depolarization [TAS]
- negative regulation of neuron apoptotic process [IDA]
- neuron apoptotic process [TAS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- positive regulation of B cell proliferation [IMP]
- positive regulation of cell growth [IDA]
- positive regulation of intrinsic apoptotic signaling pathway [TAS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- protein polyubiquitination [IDA]
- regulation of calcium ion transport [IDA]
- regulation of mitochondrial membrane permeability [ISS]
- regulation of mitochondrial membrane potential [ISS]
- regulation of protein heterodimerization activity [IDA]
- regulation of protein homodimerization activity [IDA]
- regulation of transmembrane transporter activity [IDA]
- release of cytochrome c from mitochondria [ISS, NAS]
- response to cytokine [IDA]
- response to drug [IDA, IMP]
- response to iron ion [IDA]
- response to nicotine [IDA]
- response to radiation [NAS]
- response to toxic substance [IDA]
- transmembrane transport [IDA]
Gene Ontology Molecular Function- BH3 domain binding [IPI]
- channel activity [IDA]
- channel inhibitor activity [IDA]
- identical protein binding [IPI]
- protease binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- ubiquitin protein ligase binding [IPI]
- BH3 domain binding [IPI]
- channel activity [IDA]
- channel inhibitor activity [IDA]
- identical protein binding [IPI]
- protease binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
PMAIP1
Gene Ontology Biological Process
- T cell homeostasis [ISS]
- apoptotic process [IMP, TAS]
- cellular response to glucose starvation [IMP]
- cellular response to hypoxia [IEP]
- defense response to virus [IDA]
- intrinsic apoptotic signaling pathway [IDA, TAS]
- intrinsic apoptotic signaling pathway by p53 class mediator [IMP]
- negative regulation of mitochondrial membrane potential [ISS]
- positive regulation of DNA damage response, signal transduction by p53 class mediator [IMP]
- positive regulation of apoptotic process [IDA, IMP]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- positive regulation of glucose metabolic process [IDA]
- positive regulation of intrinsic apoptotic signaling pathway [IDA, TAS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- positive regulation of protein oligomerization [IDA]
- positive regulation of release of cytochrome c from mitochondria [IDA, IMP]
- proteasomal protein catabolic process [IDA]
- reactive oxygen species metabolic process [IDA]
- regulation of mitochondrial membrane permeability [IDA]
- response to dsRNA [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.
Apoptosis is initiated when Bcl-2 and its prosurvival relatives are engaged by proapoptotic BH3-only proteins via interaction of its BH3 domain with a groove on the Bcl-2-like proteins. These interactions have been considered promiscuous, but our analysis of the affinity of eight BH3 peptides for five Bcl-2-like proteins has revealed that the interactions vary over 10,000-fold in affinity, and accordingly, ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PMAIP1 BCL2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID