BAIT

RIPK4

ANKK2, ANKRD3, DIK, NKRD3, PKK, PPS2, RIP4
receptor-interacting serine-threonine kinase 4
GO Process (2)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

AKAP8L

HA95, HAP95, NAKAP, NAKAP95, HRIHFB2018
A kinase (PRKA) anchor protein 8-like
GO Process (0)
GO Function (3)
GO Component (4)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

RIPK4 activity in keratinocytes is controlled by the SCFβ-TrCP ubiquitin ligase to maintain cortical actin organization.

Tanghe G, Urwyler-Roesselet C, De Groote P, Dejardin E, De Bock PJ, Gevaert K, Vandenabeele P, Declercq W

RIPK4 is a key player in epidermal differentiation and barrier formation. RIPK4 signaling pathways controlling keratinocyte proliferation and differentiation depend on its kinase activity leading to Dvl2, Pkp1 and IRF6 phosphorylation and NF-κB activation. However, the mechanism regulating RIPK4 activity levels remains elusive. We show that cultured keratinocytes display constitutive active phosphorylated RIPK4 while PKC signaling can trigger RIPK4 activation ... [more]

Cell. Mol. Life Sci. Dec. 01, 2017; 75(15);2827-2841 [Pubmed: 29435596]

Throughput

  • High Throughput

Curated By

  • BioGRID