BAIT
STC-1
CELE_F54C9.2, F54C9.2
stc-1 encodes an ATPase that is similar to the vertebrate HSPA13/STCH proteins that are members of the heat shock protein 70 family; by homology, STC-1 is predicted to function as an ER chaperone, and loss of stc-1 activity results in induction of an hsp-4::gfp transgene and increased aggregation of a heterologously expressed mutant human SOD1 protein in C. elegans neurons.
GO Process (6)
GO Function (0)
GO Component (0)
Caenorhabditis elegans
PREY
CLEC-80
CELE_Y54G2A.39
Protein CLEC-80
GO Process (0)
GO Function (0)
GO Component (0)
Caenorhabditis elegans
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
EPIC: software toolkit for elution profile-based inference of protein complexes.
Protein complexes are key macromolecular machines of the cell, but their description remains incomplete. We and others previously reported an experimental strategy for global characterization of native protein assemblies based on chromatographic fractionation of biological extracts coupled to precision mass spectrometry analysis (chromatographic fractionation-mass spectrometry, CF-MS), but the resulting data are challenging to process and interpret. Here, we describe EPIC ... [more]
Nat. Methods Jul. 15, 2019; (); [Pubmed: 31308550]
Quantitative Score
- 0.596 [Confidence Score]
Throughput
- High Throughput
Additional Notes
- High confidence protein interactions have an EPIC PPI score >= 0.5
Curated By
- BioGRID