Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

Publication

A central role for TOR signalling in a yeast model for juvenile CLN3 disease.

Bond ME, Brown R, Rallis C, Baehler J, Mole SE

Yeasts provide an excellent genetically tractable eukaryotic system for investigating the function of genes in their biological context, and are especially relevant for those conserved genes that cause disease. We study the role of btn1, the orthologue of a human gene that underlies an early onset neurodegenerative disease (juvenile CLN3 disease, neuronal ceroid lipofuscinosis (NCLs) or Batten disease) in the ... [more]

Microb Cell Nov. 11, 2015; 2(12);466-480 [Pubmed: 28357272]

Throughput

High Throughput

Ontology Terms

colony size (APO:0000063)

Curated By

BioGRID

Interaction Summary

BTN1

Gene Ontology Biological Process

Gene Ontology Cellular Component

SPAC922.05C

Gene Ontology Molecular Function