BAIT

NSP2AB

nsp2, sars1ab, orf1ab, SARS-CoV nsp2ab, SARS-CoV nsp2, SARS-CoV sars1ab, orf1ab-nsp2, orf1ab-nsp2ab, pp1ab, p65 homolog, R1AB_CVHSA, PRO_0000037310, SARS-CoV-1ab-nsp2ab
Non-structural protein 2; nsp2; p65 homolog
COVID-19 Coronavirus Project
GO Process (0)
GO Function (0)
GO Component (0)
Severe acute respiratory syndrome coronavirus
PREY

SLC46A3

FKSG16, RP11-97E23.2
solute carrier family 46, member 3
GO Process (0)
GO Function (0)
GO Component (1)

Gene Ontology Cellular Component

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors.

Pfefferle S, Schoepf J, Koegl M, Friedel CC, Mueller MA, Carbajo-Lozoya J, Stellberger T, von Dall'Armi E, Herzog P, Kallies S, Niemeyer D, Ditt V, Kuri T, Zuest R, Pumpor K, Hilgenfeld R, Schwarz F, Zimmer R, Steffen I, Weber F, Thiel V, Herrler G, Thiel HJ, Schwegmann-Wessels C, Poehlmann S, Haas J, Drosten C, von Brunn A

Coronaviruses (CoVs) are important human and animal pathogens that induce fatal respiratory, gastrointestinal and neurological disease. The outbreak of the severe acute respiratory syndrome (SARS) in 2002/2003 has demonstrated human vulnerability to (Coronavirus) CoV epidemics. Neither vaccines nor therapeutics are available against human and animal CoVs. Knowledge of host cell proteins that take part in pivotal virus-host interactions could define ... [more]

PLoS Pathog. Oct. 01, 2011; 7(10);e1002331 [Pubmed: 22046132]

Throughput

  • High Throughput

Additional Notes

  • validated candidates from HTYTH screen

Curated By

  • BioGRID