BAIT
ORF7B
SARS-CoV2 ORF7b, SARS-CoV-2 ORF7b, 7b, NS7B_SARS2, PRO_0000449799, GU280_gp08
Protein non-structural 7b
GO Process (0)
GO Function (0)
GO Component (0)
Severe acute respiratory syndrome coronavirus 2
PREY
SLC25A17
PMP34, RP3-362J20.2
solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17
GO Process (12)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
- ADP transport [IDA]
- AMP transport [IDA]
- ATP transport [IGI]
- FAD transmembrane transport [IDA]
- NAD transport [IDA]
- cellular lipid metabolic process [TAS]
- coenzyme A transmembrane transport [IDA]
- fatty acid alpha-oxidation [TAS]
- fatty acid beta-oxidation [IGI]
- fatty acid transport [IGI]
- nucleotide transmembrane transport [IDA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- ADP transmembrane transporter activity [IDA]
- AMP transmembrane transporter activity [IDA]
- ATP transmembrane transporter activity [IGI]
- FAD transmembrane transporter activity [IDA]
- FMN transmembrane transporter activity [IDA]
- NAD transporter activity [IDA]
- chaperone binding [IPI]
- coenzyme A transmembrane transporter activity [IDA]
- protein binding [IPI]
- ADP transmembrane transporter activity [IDA]
- AMP transmembrane transporter activity [IDA]
- ATP transmembrane transporter activity [IGI]
- FAD transmembrane transporter activity [IDA]
- FMN transmembrane transporter activity [IDA]
- NAD transporter activity [IDA]
- chaperone binding [IPI]
- coenzyme A transmembrane transporter activity [IDA]
- protein binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Global BioID-based SARS-CoV-2 proteins proximal interactome unveils novel ties between viral polypeptides and host factors involved in multiple COVID19-associated mechanisms
The worldwide SARS-CoV-2 outbreak poses a serious challenge to human societies and economies. SARS-CoV-2 proteins orchestrate complex pathogenic mechanisms that underlie COVID-19 disease. Thus, understanding how viral polypeptides rewire host protein networks enables better-founded therapeutic research. In complement to existing proteomic studies, in this study we define the first proximal interaction network of SARS-CoV-2 proteins, at the whole proteome level ... [more]
Status: Preliminary Report
Throughput
- High Throughput
Additional Notes
- BioID
- To facilitate data interpretation, an arbitrary filter was used to filter out human prey proteins connected to 8 or more viral bait proteins. High confidence interactors had an FDR < 0.01 and were detected by 7 or fewer viral bait proteins.
Curated By
- BioGRID