KRT1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
KNG1
Gene Ontology Biological Process
- blood coagulation [TAS]
- blood coagulation, intrinsic pathway [TAS]
- inflammatory response [TAS]
- negative regulation of blood coagulation [IDA]
- negative regulation of cell adhesion [IDA]
- negative regulation of endopeptidase activity [IDA]
- negative regulation of proteolysis [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of apoptotic process [NAS]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of renal sodium excretion [TAS]
- positive regulation of urine volume [TAS]
- smooth muscle contraction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Mapping binding domains of kininogens on endothelial cell cytokeratin 1.
Human cytokeratin 1 (CK1) in human umbilical vein endothelial cells (HUVEC) is expressed on their membranes and is able to bind high molecular weight kininogen (HK) (Hasan, A. A. K., Zisman, T., and Schmaier, A. H. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 3615-3620). New investigations have been performed to demonstrate the HK binding domain on CK1. Four ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID