USP22
Gene Ontology Biological Process
- histone H4 acetylation [ISO]
- histone deubiquitination [IBA, ISO]
- histone ubiquitination [ISO]
- positive regulation of mitotic cell cycle [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IDA, ISO]
- proteolysis [ISO]
- regulation of proteasomal protein catabolic process [IBA]
- regulation of transcription, DNA-templated [IBA]
- ubiquitin-dependent protein catabolic process [IC]
Gene Ontology Molecular Function- H4 histone acetyltransferase activity [ISO]
- cysteine-type endopeptidase activity [IBA]
- enzyme binding [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO]
- transcription coactivator activity [ISO]
- ubiquitin thiolesterase activity [IBA]
- ubiquitin-specific protease activity [IDA, ISO]
- H4 histone acetyltransferase activity [ISO]
- cysteine-type endopeptidase activity [IBA]
- enzyme binding [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO]
- transcription coactivator activity [ISO]
- ubiquitin thiolesterase activity [IBA]
- ubiquitin-specific protease activity [IDA, ISO]
Gene Ontology Cellular Component
XPC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
USP22 Functions as an Oncogenic Driver in Prostate Cancer by Regulating Cell Proliferation and DNA Repair.
Emerging evidence indicates the deubiquitinase USP22 regulates transcriptional activation and modification of target substrates to promote pro-oncogenic phenotypes. Here, in vivo characterization of tumor-associated USP22 upregulation and unbiased interrogation of USP22-regulated functions in vitro demonstrated critical roles for USP22 in prostate cancer. Specifically, clinical datasets validated that USP22 expression is elevated in prostate cancer, and a novel murine model demonstrated ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID