BAIT
CD80
B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7
CD80 molecule
GO Process (16)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell activation [IC]
- T cell costimulation [TAS]
- cell-cell signaling [IC]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- intracellular signal transduction [NAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of T-helper 1 cell differentiation [NAS]
- positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process [NAS]
- positive regulation of interleukin-2 biosynthetic process [NAS]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of signal transduction [NAS]
- positive regulation of transcription, DNA-templated [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SLC25A17
PMP34, RP3-362J20.2
solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17
GO Process (12)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
- ADP transport [IDA]
- AMP transport [IDA]
- ATP transport [IGI]
- FAD transmembrane transport [IDA]
- NAD transport [IDA]
- cellular lipid metabolic process [TAS]
- coenzyme A transmembrane transport [IDA]
- fatty acid alpha-oxidation [TAS]
- fatty acid beta-oxidation [IGI]
- fatty acid transport [IGI]
- nucleotide transmembrane transport [IDA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- ADP transmembrane transporter activity [IDA]
- AMP transmembrane transporter activity [IDA]
- ATP transmembrane transporter activity [IGI]
- FAD transmembrane transporter activity [IDA]
- FMN transmembrane transporter activity [IDA]
- NAD transporter activity [IDA]
- chaperone binding [IPI]
- coenzyme A transmembrane transporter activity [IDA]
- protein binding [IPI]
- ADP transmembrane transporter activity [IDA]
- AMP transmembrane transporter activity [IDA]
- ATP transmembrane transporter activity [IGI]
- FAD transmembrane transporter activity [IDA]
- FMN transmembrane transporter activity [IDA]
- NAD transporter activity [IDA]
- chaperone binding [IPI]
- coenzyme A transmembrane transporter activity [IDA]
- protein binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.937835431 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.937835431, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID