ELANE
Gene Ontology Biological Process
- cellular calcium ion homeostasis [NAS]
- collagen catabolic process [TAS]
- defense response to bacterium [IDA]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- negative regulation of chemokine biosynthetic process [IDA]
- negative regulation of chemotaxis [NAS]
- negative regulation of inflammatory response [NAS]
- negative regulation of interleukin-8 biosynthetic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of MAP kinase activity [NAS]
- positive regulation of interleukin-8 biosynthetic process [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- protein catabolic process [NAS]
- proteolysis [IDA]
- response to UV [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
KNG1
Gene Ontology Biological Process
- blood coagulation [TAS]
- blood coagulation, intrinsic pathway [TAS]
- inflammatory response [TAS]
- negative regulation of blood coagulation [IDA]
- negative regulation of cell adhesion [IDA]
- negative regulation of endopeptidase activity [IDA]
- negative regulation of proteolysis [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of apoptotic process [NAS]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of renal sodium excretion [TAS]
- positive regulation of urine volume [TAS]
- smooth muscle contraction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Proteolytic Processing)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Attenuated kinin release from human neutrophil elastase-pretreated kininogens by tissue and plasma kallikreins.
Components of kinin-forming systems operating at inflammatory sites are likely to interact with elastase that is released by recruited neutrophils and may, at least temporarily, constitute the major proteolytic activity present at these sites. The aim of this work was to determine the effect of kininogen degradation by human neutrophil elastase (HNE) on kinin generation by tissue and plasma kallikreins. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID