BAIT
TOP3B
TOP3B1
topoisomerase (DNA) III beta
GO Process (0)
GO Function (2)
GO Component (2)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [IDA]
- nucleus [IDA]
Homo sapiens
PREY
ERCC2
COFS2, EM9, TFIIH, TTD, XPD
excision repair cross-complementation group 2
GO Process (28)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- 7-methylguanosine mRNA capping [TAS]
- ATP catabolic process [IDA, TAS]
- DNA duplex unwinding [IDA]
- DNA repair [TAS]
- UV protection [IGI]
- apoptotic process [IMP]
- chromosome segregation [IMP]
- gene expression [TAS]
- hair cell differentiation [IMP]
- nucleotide-excision repair [IGI, NAS, TAS]
- nucleotide-excision repair, DNA damage removal [TAS]
- nucleotide-excision repair, DNA incision [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of viral transcription [TAS]
- protein phosphorylation [IDA]
- regulation of mitotic cell cycle phase transition [IMP]
- response to oxidative stress [IMP]
- small molecule metabolic process [TAS]
- termination of RNA polymerase I transcription [TAS]
- transcription elongation from RNA polymerase I promoter [TAS]
- transcription elongation from RNA polymerase II promoter [TAS]
- transcription from RNA polymerase I promoter [TAS]
- transcription from RNA polymerase II promoter [IDA, TAS]
- transcription initiation from RNA polymerase I promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription-coupled nucleotide-excision repair [IDA, TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
A dual-activity topoisomerase complex regulates mRNA translation and turnover.
Topoisomerase 3? (TOP3B) and TDRD3 form a dual-activity topoisomerase complex that interacts with FMRP and can change the topology of both DNA and RNA. Here, we investigated the post-transcriptional influence of TOP3B and associated proteins on mRNA translation and turnover. First, we discovered that in human HCT116 colon cancer cells, knock-out (KO) of TOP3B had similar effects on mRNA turnover ... [more]
Nucleic Acids Res Jul. 08, 2022; 50(12);7013-7033 [Pubmed: 35748872]
Throughput
- High Throughput
Curated By
- BioGRID