BAIT
TOP3B
TOP3B1
topoisomerase (DNA) III beta
GO Process (0)
GO Function (2)
GO Component (2)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [IDA]
- nucleus [IDA]
Homo sapiens
PREY
MEGF8
C19orf49, CRPT2, EGFL4, SBP1
multiple EGF-like-domains 8
GO Process (15)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- BMP signaling pathway [ISS]
- cell migration involved in gastrulation [IMP]
- craniofacial suture morphogenesis [IMP]
- determination of digestive tract left/right asymmetry [ISS]
- determination of heart left/right asymmetry [IMP]
- embryonic heart tube left/right pattern formation [ISS]
- embryonic heart tube morphogenesis [ISS]
- embryonic limb morphogenesis [ISS]
- embryonic skeletal system morphogenesis [ISS]
- epiboly involved in gastrulation with mouth forming second [IMP]
- fasciculation of sensory neuron axon [ISS]
- left/right pattern formation [IMP]
- limb morphogenesis [IMP]
- positive regulation of axon extension involved in axon guidance [ISS]
- regulation of gene expression [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
A dual-activity topoisomerase complex regulates mRNA translation and turnover.
Topoisomerase 3? (TOP3B) and TDRD3 form a dual-activity topoisomerase complex that interacts with FMRP and can change the topology of both DNA and RNA. Here, we investigated the post-transcriptional influence of TOP3B and associated proteins on mRNA translation and turnover. First, we discovered that in human HCT116 colon cancer cells, knock-out (KO) of TOP3B had similar effects on mRNA turnover ... [more]
Nucleic Acids Res Jul. 08, 2022; 50(12);7013-7033 [Pubmed: 35748872]
Throughput
- High Throughput
Curated By
- BioGRID