BAIT
TOP3B
TOP3B1
topoisomerase (DNA) III beta
GO Process (0)
GO Function (2)
GO Component (2)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [IDA]
- nucleus [IDA]
Homo sapiens
PREY
WNT7B
RP11-435J19.1
wingless-type MMTV integration site family, member 7B
GO Process (36)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
- Wnt signaling pathway [IBA, ISS]
- canonical Wnt signaling pathway [ISS]
- cell fate commitment [IBA]
- cellular metabolic process [ISS]
- cellular response to retinoic acid [IEP]
- central nervous system vasculogenesis [ISS]
- chorio-allantoic fusion [ISS]
- developmental growth involved in morphogenesis [ISS]
- embryonic organ development [ISS]
- embryonic placenta morphogenesis [ISS]
- establishment or maintenance of polarity of embryonic epithelium [ISS]
- fibroblast proliferation [IEP]
- forebrain regionalization [IEP]
- homeostatic process [ISS]
- in utero embryonic development [ISS]
- inner medullary collecting duct development [ISS]
- lens fiber cell development [ISS]
- lobar bronchus development [ISS]
- lung development [ISS]
- lung epithelium development [ISS]
- lung morphogenesis [ISS]
- mammary gland epithelium development [IEP]
- metanephric collecting duct development [ISS]
- metanephric epithelium development [ISS]
- metanephric loop of Henle development [ISS]
- metanephros morphogenesis [ISS]
- neuron differentiation [IEP]
- outer medullary collecting duct development [ISS]
- oxygen homeostasis [ISS]
- positive regulation of JNK cascade [IBA]
- positive regulation of osteoblast differentiation [ISS]
- renal inner medulla development [ISS]
- renal outer medulla development [ISS]
- stem cell proliferation [IEP]
- synapse organization [ISS]
- trachea cartilage morphogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
A dual-activity topoisomerase complex regulates mRNA translation and turnover.
Topoisomerase 3? (TOP3B) and TDRD3 form a dual-activity topoisomerase complex that interacts with FMRP and can change the topology of both DNA and RNA. Here, we investigated the post-transcriptional influence of TOP3B and associated proteins on mRNA translation and turnover. First, we discovered that in human HCT116 colon cancer cells, knock-out (KO) of TOP3B had similar effects on mRNA turnover ... [more]
Nucleic Acids Res Jul. 08, 2022; 50(12);7013-7033 [Pubmed: 35748872]
Throughput
- High Throughput
Curated By
- BioGRID