BAIT

FBXO22

FBX22, FISTC1
F-box protein 22
Cell Cycle - Senescence Project
UPS Project
GO Process (2)
GO Function (1)
GO Component (0)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Homo sapiens
PREY

AKAP8L

HA95, HAP95, NAKAP, NAKAP95, HRIHFB2018
A kinase (PRKA) anchor protein 8-like
GO Process (0)
GO Function (3)
GO Component (4)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

Zhu XN, Wei YS, Yang Q, Liu HR, Zhi Z, Zhu D, Xia L, Hong DL, Yu Y, Chen GQ

Selectively targeting leukemia stem cells (LSCs) is a promising approach in treating acute myeloid leukemia (AML), for which identification of such therapeutic targets is critical. Increasing lines of evidence indicate that FBXO22 plays a critical role in solid tumor development and therapy response. However, its potential roles in leukemogenesis remain largely unknown.We established a mixed lineage leukemia (MLL)-AF9-induced AML model ... [more]

J Hematol Oncol Feb. 11, 2023; 16(1);9 [Pubmed: 36774506]

Throughput

  • Low Throughput

Curated By

  • BioGRID