An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA.

Kasuga Y, Ouda R, Watanabe M, Sun X, Kimura M, Hatakeyama S, Kobayashi KS

Major histocompatibility complex (MHC) class I and II molecules play critical roles in the activation and regulation of adaptive immunity through antigen presentation to CD8+ and CD4+ T cells, respectively. Strict regulation of MHC expression is critical for proper immune responses. CIITA (MHC class II transactivator), an NLR (nucleotide-binding domain, leucine-rich-repeat containing) protein, is a master regulator of MHC class ... [more]

Proc Natl Acad Sci U S A Jun. 13, 2023; 120(24);e2218955120 [Pubmed: 37279268]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

CIITA

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA binding [TAS]activating transcription factor binding [IPI]protein C-terminus binding [IPI]protein binding [IPI]protein complex binding [IDA]transcription coactivator activity [TAS]transcription regulatory region DNA binding [IDA]

Gene Ontology Cellular Component

ATAD3A