KNG1
Gene Ontology Biological Process
- blood coagulation [TAS]
- blood coagulation, intrinsic pathway [TAS]
- inflammatory response [TAS]
- negative regulation of blood coagulation [IDA]
- negative regulation of cell adhesion [IDA]
- negative regulation of endopeptidase activity [IDA]
- negative regulation of proteolysis [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of apoptotic process [NAS]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of renal sodium excretion [TAS]
- positive regulation of urine volume [TAS]
- smooth muscle contraction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SERPINC1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Cross-Linking-MS (XL-MS)
An interaction is detected between two proteins using chemically reactive or photo-activatable cross-linking reagents that covalently link amino acids in close proximity, followed by mass spectrometry analysis to identify the linked peptides (reviewed in PMID 37406423, 37104977). Experiments may be carried with live cells or cell lysates in which all proteins are expressed at endogenous levels (e.g. PMID 34349018, 35235311) or with recombinant proteins (e.g., PMID 28537071).
Publication
Cross-Linking Mass Spectrometry Uncovers Interactions Between High-Density Lipoproteins and the SARS-CoV-2 Spike Glycoprotein.
High-density lipoprotein (HDL) levels are reduced in patients with coronavirus disease 2019 (COVID-19), and the extent of this reduction is associated with poor clinical outcomes. While lipoproteins are known to play a key role during the life cycle of the hepatitis C virus, their influence on coronavirus (CoV) infections is poorly understood. In this study, we utilize cross-linking mass spectrometry ... [more]
Throughput
- High Throughput
Additional Notes
- XL-MS protein interactions identified in plasma isolated from patients in intensive care with confirmed COVID-19 (Table S1).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SERPINC1 KNG1 | Cross-Linking-MS (XL-MS) Cross-Linking-MS (XL-MS) An interaction is detected between two proteins using chemically reactive or photo-activatable cross-linking reagents that covalently link amino acids in close proximity, followed by mass spectrometry analysis to identify the linked peptides (reviewed in PMID 37406423, 37104977). Experiments may be carried with live cells or cell lysates in which all proteins are expressed at endogenous levels (e.g. PMID 34349018, 35235311) or with recombinant proteins (e.g., PMID 28537071). | High | - | BioGRID | 3724103 |
Curated By
- BioGRID