BAIT
POLD1
CDC2, CRCS10, MDPL, POLD
polymerase (DNA directed), delta 1, catalytic subunit
GO Process (20)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- DNA repair [TAS]
- DNA replication [IMP]
- DNA replication proofreading [IBA]
- DNA replication, removal of RNA primer [IBA]
- DNA strand elongation involved in DNA replication [TAS]
- DNA synthesis involved in DNA repair [IDA, IMP]
- base-excision repair [TAS]
- base-excision repair, gap-filling [IDA]
- fatty acid homeostasis [IMP]
- mitotic cell cycle [TAS]
- nucleotide-excision repair [TAS]
- nucleotide-excision repair, DNA gap filling [IC, IMP, TAS]
- regulation of mitotic cell cycle [IBA]
- response to UV [TAS]
- small molecule metabolic process [TAS]
- telomere maintenance [TAS]
- telomere maintenance via recombination [TAS]
- telomere maintenance via semi-conservative replication [TAS]
- transcription-coupled nucleotide-excision repair [TAS]
- translesion synthesis [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TPR
translocated promoter region, nuclear basket protein
GO Process (37)
GO Function (12)
GO Component (13)
Gene Ontology Biological Process
- MAPK import into nucleus [IMP]
- RNA export from nucleus [IMP]
- RNA import into nucleus [IDA]
- carbohydrate metabolic process [TAS]
- cellular response to heat [IDA]
- cellular response to interferon-alpha [ISS]
- cytokine-mediated signaling pathway [TAS]
- glucose transport [TAS]
- hexose transport [TAS]
- mRNA export from nucleus in response to heat stress [IDA]
- mitotic cell cycle [TAS]
- mitotic nuclear envelope disassembly [TAS]
- mitotic spindle assembly checkpoint [IMP]
- negative regulation of RNA export from nucleus [IDA, IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of translational initiation [IMP]
- nuclear matrix organization [IMP]
- nuclear pore complex assembly [IMP]
- nuclear pore organization [IMP]
- positive regulation of heterochromatin assembly [IMP]
- positive regulation of intracellular protein transport [IMP]
- positive regulation of mitotic cell cycle spindle assembly checkpoint [IMP]
- positive regulation of protein export from nucleus [ISS]
- positive regulation of protein import into nucleus [IMP]
- protein export from nucleus [IMP]
- protein import into nucleus [IDA, IMP]
- regulation of glucose transport [TAS]
- regulation of mRNA export from nucleus [IMP]
- regulation of mitotic sister chromatid separation [IMP]
- regulation of protein export from nucleus [IMP]
- regulation of protein import into nucleus [IMP]
- regulation of protein stability [IMP]
- regulation of spindle assembly involved in mitosis [IMP]
- response to epidermal growth factor [IDA]
- small molecule metabolic process [TAS]
- transmembrane transport [TAS]
- viral process [TAS]
Gene Ontology Molecular Function- chromatin binding [IDA]
- dynein complex binding [IDA]
- heat shock protein binding [IDA]
- mRNA binding [IDA]
- mitogen-activated protein kinase binding [IDA]
- nucleocytoplasmic transporter activity [IDA]
- poly(A) RNA binding [IDA]
- protein anchor [IMP]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- transporter activity [IMP]
- tubulin binding [IDA]
- chromatin binding [IDA]
- dynein complex binding [IDA]
- heat shock protein binding [IDA]
- mRNA binding [IDA]
- mitogen-activated protein kinase binding [IDA]
- nucleocytoplasmic transporter activity [IDA]
- poly(A) RNA binding [IDA]
- protein anchor [IMP]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- transporter activity [IMP]
- tubulin binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC.
To date, most studies on the DNA polymerase, POLD1, have focused on the effect of POLD1 inactivation mutations in tumors. However, the implications of high POLD1 expression in tumorigenesis remains elusive. Here, we determine that POLD1 has a pro-carcinogenic role in bladder cancer (BLCA) and is associated to the malignancy and prognosis of BLCA. Our studies demonstrate that POLD1 promotes ... [more]
Nat Commun Apr. 27, 2023; 14(1);2421 [Pubmed: 37105989]
Throughput
- High Throughput
Additional Notes
- Affinity capture MS was carried out to identify high confidence protein interactors that are negative in controls and have >2 unique peptides
Curated By
- BioGRID