BAIT

NLRP6

AVR, CLR11.4, NALP6, NAVR, NAVR/AVR, PAN3, PYPAF5
NLR family, pyrin domain containing 6
GO Process (2)
GO Function (1)
GO Component (0)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Homo sapiens
PREY

MRPL53

L53MT
mitochondrial ribosomal protein L53
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

NLRP6 potentiates PI3K/AKT signalling by promoting autophagic degradation of p85? to drive tumorigenesis.

Zhi F, Li B, Zhang C, Xia F, Wang R, Xie W, Cai S, Zhang D, Kong R, Hu Y, Yang Y, Peng Y, Cui J

The PI3K/AKT pathway plays an essential role in tumour development. NOD-like receptors (NLRs) regulate innate immunity and are implicated in cancer, but whether they are involved in PI3K/AKT pathway regulation is poorly understood. Here, we report that NLRP6 potentiates the PI3K/AKT pathway by binding and destabilizing p85?, the regulatory subunit of PI3K. Mechanistically, NLRP6 recruits the E3 ligase RBX1 to ... [more]

Nat Commun Sep. 28, 2023; 14(1);6069 [Pubmed: 37770465]

Throughput

  • High Throughput

Curated By

  • BioGRID