BAIT
PIP82
CG11219, Dmel\CG11219, Dmel_CG11219
CG11219 gene product from transcript CG11219-RA
GO Process (1)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
Drosophila melanogaster
PREY
CHICO
BcDNA.GH11263, BcDNA:GH11263, CG5686, Dmel\CG5686, IRS, IRS/chico, anon-WO0078940.1, anon-WO0078940.4, chic, dIRS, fs(2)4, fs(2)ry4, Dmel_CG5686
CG5686 gene product from transcript CG5686-RB
GO Process (26)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- aging [IMP]
- cell morphogenesis [IMP]
- determination of adult lifespan [IMP, TAS]
- germ-line stem-cell niche homeostasis [IMP]
- growth of a germarium-derived egg chamber [IMP]
- insulin receptor signaling pathway [IGI, IPI, NAS, TAS]
- insulin-like growth factor receptor signaling pathway [ISS]
- lipid metabolic process [IMP]
- male germ-line stem cell asymmetric division [IMP]
- metabolic process [TAS]
- multicellular organism growth [IMP]
- olfactory learning [IMP]
- positive regulation of cell growth [NAS]
- positive regulation of cell size [NAS, TAS]
- positive regulation of immune response [IMP]
- positive regulation of multicellular organism growth [IMP, TAS]
- positive regulation of organ growth [NAS, TAS]
- primary spermatocyte growth [IMP]
- regulation of activin receptor signaling pathway [IMP]
- regulation of cell size [NAS, TAS]
- regulation of multicellular organism growth [TAS]
- regulation of organ growth [IMP, NAS]
- regulation of tube length, open tracheal system [IMP]
- response to anoxia [IDA]
- response to starvation [IMP, TAS]
- vitellogenesis [IMP]
Gene Ontology Molecular Function
Drosophila melanogaster
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Proximity labeling reveals interactions necessary to maintain the distinct apical domains of Drosophila photoreceptors.
Specialized membrane and cortical protein regions are common features of cells and are utilized to isolate differential cellular functions. In Drosophila photoreceptors, the apical membrane domain is defined by two distinct morphological membranes: the rhabdomere microvilli and the stalk membrane. To define the apical cortical protein complexes, we performed proximity labeling screens utilizing the rhabdomeric-specific protein PIP82 as bait. We ... [more]
J Cell Sci Dec. 01, 2024; 137(23); [Pubmed: 39540276]
Throughput
- High Throughput
Additional Notes
- Hit in S2 cells: SAINT P = 1
- Proximity label MS was carried out to identify high confidence protein interactors in S2 cells with a SAINT P of greater than or equal to 0.8
Curated By
- BioGRID