BAIT

PFD1

GIM6, L000004367, YJL179W
Subunit of heterohexameric prefoldin; prefoldin binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation
GO Process (3)
GO Function (1)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

COG4

COD1, SEC38, SGF1, S000007660, YPR105C
Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
GO Process (5)
GO Function (0)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Synthetic Rescue

A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

Publication

Genetic Analysis Implicates the Set3/Hos2 Histone Deacetylase in the Deposition and Remodeling of Nucleosomes Containing H2A.Z.

Hang M, Smith MM

Histone variants and histone modification complexes act to regulate the functions of chromatin. In Saccharomyces cerevisiae the histone variant H2A.Z is encoded by HTZ1. Htz1 is dispensable for viability in budding yeast, but htz1Δ is synthetic sick or lethal with the null alleles of about 200 non-essential genes. One of the strongest of these interactions is with the deletion of ... [more]

Unknown Feb. 04, 2011; 0(0); [Pubmed: 21288874]

Throughput

  • High Throughput

Ontology Terms

  • colony size (APO:0000063)

Additional Notes

  • High Throughput: A modified Synthetic Genetic Array (SGA) analysis involving triple mutants was carried out to assess the genome-wide suppression of htz1 negative genetic interactions. A double mutant query strain carrying a deletion of sgf1 (suppressor) and an htz1 deletion was crossed against mini-arrays containing strains with known gene deletions that have negative genetic interactions with htz1 null mutants.

Curated By

  • BioGRID