Human RanBP3, a group of nuclear RanGTP binding proteins.
A group of novel human Ran-binding proteins, RanBP3, was identified using the yeast two-hybrid system via Ran-mediated interaction with the nucleotide exchange factor RCC1. Several open reading frames, representing putative alternatively spliced products, were established by cDNA cloning. Two of them, RanBP3-a and RanBP3-b, encode nuclear hydrophilic proteins of 499 ... and 562 amino acid residues. The sequences contain FXFG motifs, characteristic of a subgroup of nucleoporins, and a C-terminal domain showing similarity to the Ran-binding protein RanBP1. These proteins are localized in the nucleus, preferentially bind RanGTP and may be nuclear effectors of the Ran pathway.
Mesh Terms:
Alternative Splicing, Amino Acid Sequence, Carrier Proteins, Cell Cycle Proteins, Cell Nucleus, DNA-Binding Proteins, GTP-Binding Proteins, Guanine Nucleotide Exchange Factors, Hela Cells, Humans, Molecular Sequence Data, Nuclear Proteins, Nucleocytoplasmic Transport Proteins, Recombinant Proteins, Sequence Homology, Amino Acid, Transcription, Genetic, Yeasts, ran GTP-Binding Protein
Alternative Splicing, Amino Acid Sequence, Carrier Proteins, Cell Cycle Proteins, Cell Nucleus, DNA-Binding Proteins, GTP-Binding Proteins, Guanine Nucleotide Exchange Factors, Hela Cells, Humans, Molecular Sequence Data, Nuclear Proteins, Nucleocytoplasmic Transport Proteins, Recombinant Proteins, Sequence Homology, Amino Acid, Transcription, Genetic, Yeasts, ran GTP-Binding Protein
FEBS Lett.
Date: May. 15, 1998
PubMed ID: 9637251
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