Integrative Responses to High pH Stress in S. cerevisiae.
Abstract The budding yeast Saccharomyces cerevisiae grows far better at acidic than at neutral or alkaline pH. Consequently, even a modest alkalinization of the medium represents a stressful situation for this yeast. In the past few years, data generated by a combination of genome-wide techniques has demonstrated that adaptive responses ... of S. cerevisiae to high pH stress involves extensive gene remodeling as a result of the fast activation of a number of stress-related signaling pathways, such as the Rim101, the Wsc1-Pkc1-Slt2 MAP kinase, and the calcium-activated calcineurin pathways. Alkalinization of the environment also disturbs nutrient homeostasis, as deduced from its impact on iron/copper, phosphate, and glucose uptake/utilization pathways. In this review we will examine these responses, their possible interactions, and the role that they play in tolerance to high pH stress.
Mesh Terms:
Amino Acid Sequence, Animals, Basement Membrane, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Cell Movement, Cloning, Molecular, Disintegrins, Extracellular Matrix, Gene Expression Profiling, Genes, Helminth, Glycosylation, Gonads, Metalloendopeptidases, Molecular Sequence Data, Muscles, Mutation, Protein Structure, Tertiary, Recombinant Fusion Proteins, Sequence Alignment, Transgenes
Amino Acid Sequence, Animals, Basement Membrane, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Cell Movement, Cloning, Molecular, Disintegrins, Extracellular Matrix, Gene Expression Profiling, Genes, Helminth, Glycosylation, Gonads, Metalloendopeptidases, Molecular Sequence Data, Muscles, Mutation, Protein Structure, Tertiary, Recombinant Fusion Proteins, Sequence Alignment, Transgenes
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Date: Aug. 20, 2010
PubMed ID: 20726779
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